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Article |
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
Mouse genetic studies and single-cell transcriptome analysis demonstrate that TIM-3 on dendritic cells has a key role in regulating antitumour immunity via inflammasome activation and is a potential target for anticancer therapy.
- Karen O. Dixon
- , Marcin Tabaka
- & Vijay K. Kuchroo
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Letter |
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.
- Naomi McGovern
- , Amanda Shin
- & Florent Ginhoux
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Letter |
Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets
Human TRIM5α restricts HIV-1 infection of Langerhans cells through Langerin-dependent autophagy pathway.
- Carla M. S. Ribeiro
- , Ramin Sarrami-Forooshani
- & Teunis B. H. Geijtenbeek
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Letter |
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
The Tet2 enzyme, which catalyses de novo hydroxymethylation of DNA, is shown here to act as a transcriptional repressor by recruiting the histone deacetylase Hdac2 to the Il6 promoter in the course of resolution of the LPS-induced inflammatory response.
- Qian Zhang
- , Kai Zhao
- & Xuetao Cao
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Letter |
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling
The endo-lysosomal transporters SLC15A3 and SLC15A4 provide a portal of entry for extracellular bacterial products that activate the cytoplasmic sensor NOD2; these results establish the importance of endosomes as signalling platforms specialized for triggering innate immune responses.
- Norihiro Nakamura
- , Jennie R. Lill
- & Ira Mellman
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Letter |
L-Myc expression by dendritic cells is required for optimal T-cell priming
L-Myc, a paralogue of the proto-oncogene c-Myc, is shown to regulate dendritic cell homeostasis and functionality; unlike c-Myc, L-Myc is not repressed by interferons and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation.
- Wumesh KC
- , Ansuman T. Satpathy
- & Kenneth M. Murphy
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Letter |
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Dendritic cells in mice lacking NLRP10 are defective in exiting inflamed tissue, leading to impaired adaptive immunity; this could have a profound impact on the approach to treating allergic and autoimmune diseases.
- Stephanie C. Eisenbarth
- , Adam Williams
- & Richard A. Flavell
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Letter |
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
Goblet cells in the small intestine act as passages delivering small antigens to tolerance-inducing dendritic cells in the lamina propria.
- Jeremiah R. McDole
- , Leroy W. Wheeler
- & Mark J. Miller
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Letter |
Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
- Christine Moussion
- & Jean-Philippe Girard
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News |
A fight for life that united a field
Nobel-prizewinner Ralph Steinman tried to beat his cancer with vaccines based on the dendritic cells he discovered.
- Lauren Gravitz
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Letter |
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
- Nadine Laguette
- , Bijan Sobhian
- & Monsef Benkirane
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Review Article |
The myeloid cells of the central nervous system parenchyma
- Richard M. Ransohoff
- & Astrid E. Cardona
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Letter |
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Human immunodeficiency virus (HIV) fails to induce interferon in the cells that it infects, but the underlying mechanisms are not known. These authors show that the virus can in fact activate the interferon pathway in dendritic cells when the usual block to infection is bypassed. Dendritic cell activation depends on the HIV-1 capsid/cyclophilin A interaction, which is known to have a role in HIV-1 infectivity.
- Nicolas Manel
- , Brandon Hogstad
- & Dan R. Littman
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Research Highlights |
Virology: HIV spread in 3D
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity