Dementia articles within Nature

Featured

  • Article
    | Open Access

    Cryogenic electron microscopy structures of amyloid filaments extracted from patient brains reveal that the protein TAF15 forms filaments that characterize certain cases of frontotemporal lobar degeneration.

    • Stephan Tetter
    • , Diana Arseni
    •  & Benjamin Ryskeldi-Falcon

  • Article
    | Open Access

    Cryo-electron microscopy structures and mass spectrometry analyses show that TAR DNA-binding protein 43 (TDP-43) forms amyloid filaments with a distinct fold in type A frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) compared with TDP-43 filaments in type B FTLD-TDP and amyotrophic lateral sclerosis.

    • Diana Arseni
    • , Renren Chen
    •  & Benjamin Ryskeldi-Falcon

  • Article
    | Open Access

    Medin promotes the formation of vascular aggregates with amyloid-β in mouse models and in human patients with Alzheimer’s disease, and is associated with vascular defects and cognitive decline.

    • Jessica Wagner
    • , Karoline Degenhardt
    •  & Jonas J. Neher

  • Article |

    The nuclear mitotic apparatus protein NuMA helps to protect genes from oxidative damage by occupying regions around transcription start sites, binding DNA repair factors and promoting transcription following damage.

    • Swagat Ray
    • , Arwa A. Abugable
    •  & Sherif F. El-Khamisy

  • Article |

    Analyses of single-cell whole-genome sequencing data show that somatic mutations are increased in the brain of individuals with Alzheimer’s disease compared to neurotypical individuals, with a pattern of genomic damage distinct from that of normal ageing.

    • Michael B. Miller
    • , August Yue Huang
    •  & Christopher A. Walsh

  • Article |

    Cryo-electron microscopy of aggregated TDP-43 from postmortem brain tissue of individuals who had ALS with FTLD reveals a filament structure with distinct features to other neuropathological protein filaments, such as those of tau and α-synuclein.

    • Diana Arseni
    • , Masato Hasegawa
    •  & Benjamin Ryskeldi-Falcon

  • Article |

    Reduced abundance of immune-stimulating gut bacteria ameliorated the inflammatory and autoimmune phenotypes of mice with mutations in C9orf72, which in the human orthologue are linked to amyotrophic lateral sclerosis and frontotemporal dementia.

    • Aaron Burberry
    • , Michael F. Wells
    •  & Kevin Eggan

  • Article |

    The authors show that NLRP3 inflammasome is activated in microglia of patients with fronto-temporal dementia and in a mouse model of tau pathology, and that the loss of NLRP3 inflammasome function decreases tau pathology and improves cognition in mice.

    • Christina Ising
    • , Carmen Venegas
    •  & Michael T. Heneka

  • Article |

    Aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ, reduces soluble and insoluble Aβ in the brain, an action accompanied by a dose-dependent slowing of clinical decline in treated patients.

    • Jeff Sevigny
    • , Ping Chiao
    •  & Alfred Sandrock

  • Brief Communications Arising |

    • John Collinge
    • , Zane Jaunmuktane
    •  & Sebastian Brandner

  • Letter |

    Treatment of children with human cadaver-derived growth hormone (c-hGH) contaminated with prions resulted in transmission of Creutzfeldt–Jakob disease (CJD); unexpectedly, in an autopsy study of eight such iCJD patients, the authors found amyloid-β deposition in the grey matter typical of that seen in Alzheimer's disease and amyloid-β in the blood vessel walls characteristic of cerebral amyloid angiopathy, consistent with iatrogenic transmission of amyloid-β pathology in addition to CJD and suggests that healthy c-hGH-exposed individuals may also be at risk of Alzheimer's disease and cerebral amyloid angiopathy.

    • Zane Jaunmuktane
    • , Simon Mead
    •  & Sebastian Brandner

  • Letter |

    Whole-exome sequencing reveals that a rare variant of phospholipase D3 (PLD3(V232M)) segregates with Alzheimer’s disease status in two independent families and doubles risk for the disease in case–control series, and that several other PLD3 variants increase risk for Alzheimer’s disease in African Americans and people of European descent.

    • Carlos Cruchaga
    • , Celeste M. Karch
    •  & Alison M. Goate

  • Brief Communications Arising |

    • Christopher J. Phiel
    • , Christina A. Wilson
    •  & Peter S. Klein

  • News |

    Psychologist Margaret Gatz explains what 25 years of research have taught her about reducing the risk of dementia.

    • Gwyneth Dickey Zakaib

  • Outlook |

    As the number of Alzheimer's cases rises rapidly in an ageing global population, the need to understand this puzzling disease is growing.

    • Alison Abbott

  • News & Views |

    With age comes wisdom, or so they say. The reality is that, with age, the ability to store memories declines. One way of tackling this problem might be to raise neuronal levels of the signalling molecule EphB2. See Article p.47

    • Robert C. Malenka
    •  & Roberto Malinow

Browse broader subjects

Browse narrower subjects

Browse Dementia across other nature.com journals