Featured
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Career Feature |
How ChatGPT is transforming the postdoc experience
Around one in three respondents to Nature’s global postdoc survey are using AI chatbots to help to refine text, generate or edit code, wrangle the literature in their field and more.
- Linda Nordling
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News |
How AlphaFold and other AI tools could help us prepare for the next pandemic
Researchers are using machine-learning programs to predict the evolution of viruses and design vaccines.
- Ewen Callaway
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Article
| Open AccessUnraveling the functional dark matter through global metagenomics
A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.
- Georgios A. Pavlopoulos
- , Fotis A. Baltoumas
- & Nikos C. Kyrpides
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Article
| Open AccessLearning from prepandemic data to forecast viral escape
EVEscape, a flexible framework using deep learning and biophysical structural information, enables early identification of concerning mutations in viruses with pandemic potential, facilitating the development of vaccines and therapeutics.
- Nicole N. Thadani
- , Sarah Gurev
- & Debora S. Marks
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Editorial |
AI’s potential to accelerate drug discovery needs a reality check
Companies say the technology will contribute to faster drug development. Independent verification and clinical trials will determine whether this claim holds up.
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News Feature |
How ChatGPT and other AI tools could disrupt scientific publishing
A world of AI-assisted writing and reviewing might transform the nature of the scientific paper.
- Gemma Conroy
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Career Guide |
How to spice up your bioinformatics skill set with AI
Incorporating machine-learning tools into data analysis can accelerate discovery and free up valuable time.
- Rachael Pells
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Career Column |
Embracing the command line: my unexpected career in computational biology
A crash course in bioinformatics put Ming Tommy Tang on a different path.
- Ming Tommy Tang
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Research Briefing |
Deep learning shows how global warming affects daily rainfall
An artificial-intelligence method called deep learning has been used to detect signals of human-induced climate change in daily precipitation data. The results indicate that global warming has increased day-to-day rainfall variability in tropical and mid-latitude regions over the past 40 years.
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Perspective |
The status of the human gene catalogue
Although the catalogue of human protein-coding genes is nearing completion, the number of non-coding RNA genes remains highly uncertain, and for all genes much work remains to be done to understand their functions.
- Paulo Amaral
- , Silvia Carbonell-Sala
- & Steven L. Salzberg
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News |
AI predicts how many earthquake aftershocks will strike — and their strength
Models trained on large data sets of seismic events can estimate the number of aftershocks better than conventional models do.
- Alexandra Witze
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News |
Can AI predict who will win a Nobel Prize?
With a few modifications, ChatGPT-like models could enhance the art of identifying future laureates.
- Gemma Conroy
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Editorial |
AI will transform science — now researchers must tame it
A new Nature series will explore the many ways in which artificial intelligence is changing science — for better and for worse.
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Career Column |
What’s the best chatbot for me? Researchers put LLMs through their paces
When it comes to large language models, there’s one for every occasion. Find the most appropriate match for you in our AI speed-dating feature.
- Elizabeth M. Humphries
- , Carrie Wright
- & Jeffrey T. Leek
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Comment |
AI tools as science policy advisers? The potential and the pitfalls
Large language models and other artificial-intelligence systems could be excellent at synthesizing scientific evidence for policymakers — but only with appropriate safeguards and humans in the loop.
- Chris Tyler
- , K. L. Akerlof
- & William J. Sutherland
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News Feature |
AI and science: what 1,600 researchers think
A Nature survey finds that scientists are concerned, as well as excited, by the increasing use of artificial-intelligence tools in research.
- Richard Van Noorden
- & Jeffrey M. Perkel
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News Feature |
Science and the new age of AI
A Nature special on how AI is transforming the scientific enterprise.
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News Feature |
How to stop AI deepfakes from sinking society — and science
Deceptive videos and images created using generative AI could sway elections, crash stock markets and ruin reputations. Researchers are developing methods to limit their harm.
- Nicola Jones
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News |
AlphaFold touted as next big thing for drug discovery — but is it?
Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry.
- Carrie Arnold
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News Q&A |
‘They went to the bar at noon’: what this virtual AI village is teaching researchers
Researcher Joon Park talks about making a small town of AI-powered agents open-source.
- Matthew Hutson
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Article
| Open AccessTransgenic ferret models define pulmonary ionocyte diversity and function
Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.
- Feng Yuan
- , Grace N. Gasser
- & John F. Engelhardt
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Comment |
AI can help to speed up drug discovery — but only if we give it the right data
Artificial-intelligence tools that enable companies to share data about drug candidates while keeping sensitive information safe can unleash the potential of machine learning and cutting-edge lab techniques, for the common good.
- Marissa Mock
- , Suzanne Edavettal
- & Alan Russell
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News |
AlphaFold tool pinpoints protein mutations that cause disease
Researchers have adapted the AI network to search for genetic changes linked to ill health.
- Ewen Callaway
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Outlook |
A test of artificial intelligence
As debate rages over the abilities of modern AI systems, scientists are still struggling to effectively assess machine intelligence.
- Michael Eisenstein
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News |
Why Japan is building its own version of ChatGPT
Some Japanese researchers feel that AI systems trained on foreign languages cannot grasp the intricacies of Japanese language and culture.
- Tim Hornyak
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Research Highlight |
The maths of how we wait in crowded places
Experiments at a simulated railway platform show people space themselves out regardless of obstacles.
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Article
| Open AccessUncovering new families and folds in the natural protein universe
The extent to which the AlphaFold database has structurally illuminated proteins that are challenging to annotate for function or putative biological role using standard homology-based approaches at high predicted accuracy is investigated.
- Janani Durairaj
- , Andrew M. Waterhouse
- & Joana Pereira
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News |
AI detects eye disease and risk of Parkinson’s from retinal images
Researchers have developed a model trained similarly to ChatGPT that can be adapted to evaluate multiple health conditions.
- Mariana Lenharo
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News |
‘A Pandora’s box’: map of protein-structure families delights scientists
Never-before-seen forms and unexpected connections between proteins revealed by analysis of their shapes.
- Ewen Callaway
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Article
| Open AccessClustering predicted structures at the scale of the known protein universe
The novel Foldseek clustering algorithm defines 2.30 million clusters of AlphaFold structures, identifying remote structural similarity of human immune-related proteins in prokaryotic species.
- Inigo Barrio-Hernandez
- , Jingi Yeo
- & Martin Steinegger
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News |
AI predicts chemicals’ smells from their structures
Neural network can provide descriptions, such as ‘grassy’, for a wide variety of molecules, including some that don’t exist in nature.
- Sara Reardon
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Nature Video |
AI finally beats humans at a real-life sport — drone racing
The new system combines simulation with onboard sensing and computation.
- Dan Fox
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News & Views |
Drone-racing champions outpaced by AI
An autonomous drone has competed against human drone-racing champions — and won. The victory can be attributed to savvy engineering and a type of artificial intelligence that learns mostly through trial and error.
- Guido C. H. E. de Croon
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News & Views |
Analog chip paves the way for sustainable AI
As the resources required by artificial intelligence increase unsustainably, an analog design provides an energy-efficient alternative to digital computer chips — and one that is ideally suited to neural-network computations.
- Hechen Wang
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News |
Brain-reading devices allow paralysed people to talk using their thoughts
Two studies report considerable improvements in technologies designed to help people with facial paralysis to communicate.
- Miryam Naddaf
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Article |
The complete sequence of a human Y chromosome
We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference.
- Arang Rhie
- , Sergey Nurk
- & Adam M. Phillippy
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Article |
Assembly of 43 human Y chromosomes reveals extensive complexity and variation
De novo assemblies of 43 Y chromosomes spanning 182,900 years of human evolution reveal considerable diversity in the size and structure of the human Y chromosome.
- Pille Hallast
- , Peter Ebert
- & Charles Lee
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News Feature |
Europe spent €600 million to recreate the human brain in a computer. How did it go?
The Human Brain Project wraps up in September after a decade. Nature examines its achievements and its troubled past.
- Miryam Naddaf
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Technology Feature |
Artificial-intelligence search engines wrangle academic literature
Developers want to free scientists to focus on discovery and innovation by helping them to draw connections from a massive body of literature.
- Amanda Heidt
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News |
ChatGPT-like AIs are coming to major science search engines
The Scopus, Dimensions and Web of Science databases are introducing conversational AI search.
- Richard Van Noorden
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Review Article |
Scientific discovery in the age of artificial intelligence
The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.
- Hanchen Wang
- , Tianfan Fu
- & Marinka Zitnik
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News |
AI search of Neanderthal proteins resurrects ‘extinct’ antibiotics
Scientists identify protein snippets made by extinct hominins.
- Saima Sidik
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News |
AI helps scientists to eavesdrop on endangered pink dolphins
Acoustic tracking technology could feed into conservation projects in the Amazon and beyond.
- Lilly Tozer
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News & Views |
Heat-assisted imaging enables day-like visibility at night
An imaging technique that uses a neural-network model to obtain physical information from infrared radiation improves on existing techniques in low-visibility situations, and could be deployed immediately in autonomous vehicles.
- Manish Bhattarai
- & Sophia Thompson
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Nature Podcast |
AI-enhanced night-vision lets users see in the dark
Night-vision technology gets a boost from machine learning, and the mysterious link between COVID-19 and type-1 diabetes.
- Nick Petrić Howe
- & Shamini Bundell
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Editorial |
ChatGPT is a black box: how AI research can break it open
Despite their wide use, large language models are still mysterious. Revealing their true nature is urgent and important.
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News & Views |
Cell-level reference maps for the human body take shape
The HuBMAP consortium has generated spatially resolved cell atlases for the human intestine, kidney and placenta, which enable analysis of tissue organization in unprecedented detail.
- Roser Vento-Tormo
- & Roser Vilarrasa-Blasi
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