Clostridium difficile articles within Nature

Featured

• Article | 15 November 2023

  Clostridioides difficile ferrosome organelles combat nutritional immunity

  Ferrosome organelles produced by Clostridioides difficile are required to support colonization of the inflamed gut, highlighting the potential of targeting ferrosome formation as an antimicrobial strategy against this important pathogen.

  • Hualiang Pi
  • , Rong Sun
  •  & Eric P. Skaar

• Article | 28 September 2016

  Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

  Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treating C. difficile infections.

  • Liang Tao
  • , Jie Zhang
  •  & Min Dong

• Letter | 22 October 2014

  Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

  A fraction of the intestinal microbiota as precise as a single bacterial species confers infection resistance by synthesizing Clostridium difficile-inhibiting metabolites from host-derived bile salts.

  • Charlie G. Buffie
  • , Vanni Bucci
  •  & Eric G. Pamer

• Research Highlights | 31 October 2012

  Bacteria beaten by bacteria

• News & Views | 06 October 2010

  A toxin contest

  The bacterium Clostridium difficile can cause life-threatening human disease. The question is which of the organism's two toxins is the more crucial to its pathogenicity. The answer is one or the other, or both. See Letter p.711

  • Jimmy D. Ballard