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Open Access
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Article |
Reconstitution reveals motor activation for intraflagellar transport
Reconstitution of a functional intraflagellar transport complex in Caenorhabditis elegans provides insight into the recruitment and activation of the kinesin-2 motor protein.
- Mohamed A. A. Mohamed
- , Willi L. Stepp
- & Zeynep Ökten
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Letter |
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.
- Ari J. Firestone
- , Joshua S. Weinger
- & James K. Chen
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Research Highlights |
Microtubules beat in sync
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Letter |
Functional genomic screen for modulators of ciliogenesis and cilium length
Primary cilia are tiny hair-like structures expressed on the surface of eukaryotic cells. They participate in a range of processes, such as sensing the extracellular environment and regulating signalling pathways during development. Here, a functional genomic screen is presented that used RNA interference to identify human genes involved in controlling ciliogenesis. Several positive and negative ciliogenesis modulators with broad-ranging functions were found.
- Joon Kim
- , Ji Eun Lee
- & Joseph G. Gleeson
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News & Views |
How cilia beat
Physics provides new approaches to difficult biological problems: a plausible mathematical model of how cilia and flagella beat has been formulated, but it needs to be subjected to rigorous experimental tests.
- T. J. Mitchison
- & H. M. Mitchison