Chromosome segregation articles within Nature

Featured

  • Article
    | Open Access

    Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between chromosomal instability and variation in chromatin state and gene expression.

    • Stamatis Papathanasiou
    • , Nikos A. Mynhier
    •  & David Pellman

  • Article
    | Open Access

    The CIP2A–TOPBP1 complex tethers fragmented chromosomes from micronuclei for asymmetric mitotic inheritance, explaining distinct patterns of chromosome rearrangements in cancers and genomic disorders.

    • Yu-Fen Lin
    • , Qing Hu
    •  & Peter Ly

  • Article
    | Open Access

    Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that result in non-random aneuploidy landscapes.

    • Sjoerd J. Klaasen
    • , My Anh Truong
    •  & Geert J. P. L. Kops

  • Article |

    The meiotic proteins Spo11 and Rec8, which ensure meiotic recombination and reductional chromosome segregation, have additional activities that challenge centromere stability by promoting centromeric nucleosome remodelling in both fission yeast and human cells.

    • Haitong Hou
    • , Eftychia Kyriacou
    •  & Julia Promisel Cooper

  • Article |

    The three-dimensional structure of pericentromeres in budding yeast is defined by convergent genes, which mark pericentromere borders and trap cohesin complexes loaded at centromeres, generating an architecture that allows correct chromosome segregation.

    • Flora Paldi
    • , Bonnie Alver
    •  & Adele L. Marston

  • Letter |

    During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has biophysical properties similar to those of surfactants.

    • Sara Cuylen
    • , Claudia Blaukopf
    •  & Daniel W. Gerlich

  • Letter |

    The crystal structures of the protease domain of separase are reported, showing how separase recognizes cohesin, and how phosphorylation of the cleavage site enhances separase activity.

    • Zhonghui Lin
    • , Xuelian Luo
    •  & Hongtao Yu

  • Letter |

    Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

    • Sheroy Minocherhomji
    • , Songmin Ying
    •  & Ian D. Hickson

  • Article |

    The mechanism for chromothripsis, “shattered” chromosomes that can be observed in cancer cells, is unknown; here, using live-cell imaging and single-cell sequencing, chromothripsis is shown to occur after a chromosome is isolated into a micronucleus, an abnormal nuclear structure.

    • Cheng-Zhong Zhang
    • , Alexander Spektor
    •  & David Pellman

  • Letter |

    Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M arrest.

    • Emily C. Dykhuizen
    • , Diana C. Hargreaves
    •  & Gerald R. Crabtree

  • Letter |

    Using a CO-FISH method with single-chromosome resolution, sister chromatids of the sex chromosomes, but not autosomes, are shown to segregate nonrandomly during asymmetric cell divisions of Drosophila male germline stem cells; this suggests that it is unlikely that nonrandom sister chromatid segregation serves to protect the ‘immortal strand’ to avoid replication-induced mutations as proposed previously.

    • Swathi Yadlapalli
    •  & Yukiko M. Yamashita

  • Letter |

    The current model to explain accurate chromosome segregation after DNA replication holds that kinetochore–microtubule attachments exert tension across the centromere and are stabilized by spatial separation from inner centromere-localized Aurora B; here an alternative model is presented, wherein active Aurora B produced by clustering is sufficient to ensure biorientation through a mechanism that is intrinsic to the kinetochore.

    • Christopher S. Campbell
    •  & Arshad Desai

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