Featured
-
-
Article
| Open Access
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mice by decreasing chondrocyte apoptosis.
- Doo Ri Park
- , Jihee Kim
- & Soo Young Lee
-
Article
| Open Access
Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.
- Song Ho Chang
- , Daisuke Mori
- & Taku Saito
-
Article
| Open Access
BMP9 stimulates joint regeneration at digit amputation wounds in mice
Mammalian joints have poor regenerative capacity following amputation. Here, the authors show that in mice, stimulation of the amputation wound with BMP2 and BMP9 stimulates regeneration of a synovial joint that includes bone, cartilage and a synovial cavity.
- Ling Yu
- , Lindsay A. Dawson
- & Ken Muneoka
-
Article
| Open Access
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.
- Quanbo Ji
- , Xiaojie Xu
- & Yan Wang
-
Article
| Open Access
RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects chondrocytes against apoptosis by modulating the function of heat shock proteins.
- Young-Ok Son
- , Hyo-Eun Kim
- & Jang-Soo Chun
-
Article
| Open Access
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.
- Hiroshi Kobayashi
- , Song Ho Chang
- & Taku Saito
-
Article |
G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes
The resting zone of the growth plate of mammalian long bones contains stem-like chondrocytes. Here, the authors show that G-protein stimulatory alpha subunit, Gsα, and the Gq/11α G-proteins together protect stem-like chondrocytes from apoptosis and preserve chondrocyte quiescence in mouse growth plates.
- Andrei S. Chagin
- , Karuna K. Vuppalapati
- & Henry M. Kronenberg
PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis