Chemotaxis articles within Nature Communications

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  • Article
    | Open Access

    Pores and channels within complex porous structures, such as the soil or the human gut, influence fluid flow and thus bacterial colonization. Here, Scheidweiler et al. study bacterial colonization of a model complex porous structure and show how the interactions between fluid flow, microscale structure, chemotaxis, and gradients of a quorum-sensing signaling molecule control the heterogenous accumulation of bacterial biomass.

    • David Scheidweiler
    • , Ankur Deep Bordoloi
    •  & Pietro de Anna

  • Article
    | Open Access

    Neutrophil ontogeny in zebrafish may be a continuum or consist of distinct lineages. Here the authors characterise neutrophils derived from rostral blood island and caudal haematopoietic tissue lineages and show differential gene expression and function in steady state and during wound healing.

    • Juan P. García-López
    • , Alexandre Grimaldi
    •  & Carmen G. Feijoo

  • Article
    | Open Access

    Leukotriene B4 (LTB4) is a potent lipid chemoattractant driving leukocyte migration and neutrophil swarming, but methods for its real-time detection are lacking. Here, the authors develop GEM-LTB4, a genetically encoded fluorescent biosensor, and use it to visualize leukocyte-derived LTB4 gradients.

    • Szimonetta Xénia Tamás
    • , Benoit Thomas Roux
    •  & Balázs Enyedi

  • Article
    | Open Access

    Engineering protein biosensors that respond to biomolecules by triggering cellular responses has largely relied on binding rigid molecules. Here, the authors develop a computational strategy for designing signaling complexes between conformationally dynamic proteins and peptides.

    • Robert E. Jefferson
    • , Aurélien Oggier
    •  & Patrick Barth

  • Article
    | Open Access

    African trypanosomes collectively move in a process called social motility. Here, the authors show that procyclic forms acidify their environment as a consequence of glucose metabolism, generating pH gradients by diffusion that are sensed via cyclic AMP signalling. Parasite mutants defective in cAMP signaling are inhibited in fly infection.

    • Sebastian Shaw
    • , Sebastian Knüsel
    •  & Isabel Roditi

  • Article
    | Open Access

    Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.

    • Amalia Hadjitheodorou
    • , George R. R. Bell
    •  & Julie A. Theriot

  • Article
    | Open Access

    It is unclear how bacterial cells adapt the reversible switching of flagellar motor rotation to environments of different viscosities. Here, Antani et al. show that flagellar mechanosensors allosterically control the motor’s binding affinity for the chemotaxis response regulator, CheY-P, to adapt flagellar switching over varying viscous loads.

    • Jyot D. Antani
    • , Rachit Gupta
    •  & Pushkar P. Lele

  • Article
    | Open Access

    Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.

    • Caroline Coombs
    • , Antonios Georgantzoglou
    •  & Milka Sarris

  • Article
    | Open Access

    Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in this region lead to G protein sequestration and ultimately chemotaxis defects.

    • Takero Miyagawa
    • , Hiroyasu Koteishi
    •  & Masahiro Ueda

  • Article
    | Open Access

    Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient in mammary cells.

    • Mathieu Deygas
    • , Rudy Gadet
    •  & Ivan Mikaelian

  • Article
    | Open Access

    Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.

    • Lijian Shao
    • , Jianhui Chang
    •  & Robert A. Hromas

  • Article
    | Open Access

    How bacteria migrate collectively despite individual phenotypic variation is not understood. Here, the authors show that cells spontaneously sort themselves within moving bands such that variations in individual tumble bias, a determinant of gradient climbing speed, are compensated by the local gradient steepness experienced by individuals.

    • X. Fu
    • , S. Kato
    •  & T. Emonet

  • Article
    | Open Access

    Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.

    • Salvatore Corallino
    • , Chiara Malinverno
    •  & Giorgio Scita

  • Article
    | Open Access

    HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clones in mice.

    • Florent Percher
    • , Céline Curis
    •  & Philippe V. Afonso

  • Article
    | Open Access

    Diatoms often dominate production in aquatic communities, but the amount of available dissolved silicic acid (dSi) limits their growth. Here, Bondoc et al., show that diatoms perceive gradients in dSi, and can increase the encounter with this resource by chemotaxis toward high concentrations under resource-limited conditions.

    • Karen Grace V. Bondoc
    • , Jan Heuschele
    •  & Georg Pohnert

  • Article
    | Open Access

    The signals that pattern the sympathetic nervous system are not fully understood. Here the authors show that the dorsal migration of the primary sympathetic ganglia in chick embryos is orchestrated by BDNF/TrkB signalling and requires contact with preganglionic axons.

    • Jennifer C. Kasemeier-Kulesa
    • , Jason A. Morrison
    •  & Paul M. Kulesa

  • Article
    | Open Access

    Drosophila melanogaster larvae demonstrate chemotaxis towards odours but their navigation mechanism is poorly understood. Using computer-vision tracking, Gomez-Marinet al.show that larvae ascend odour gradients using an active sampling strategy that is analogous to sniffing in vertebrates.

    • Alex Gomez-Marin
    • , Greg J. Stephens
    •  & Matthieu Louis

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