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The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein
The TORC1 complex regulates cell growth and metabolism in response to nutrient availability. Boeckstaens et al.demonstrate that following amino-acid starvation, the TORC1 effector Npr1 stimulates ammonium uptake through the Mep2 transporter by phosphorylating and inactivating an inhibitory domain.
- Mélanie Boeckstaens
- , Elisa Llinares
- & Anna Maria Marini
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| Open AccessAngiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms
Angiomotins retain the transcription co-activator YAP in the cytoplasm and thereby regulate the Hippo pathway in mammalian cultured cells. Here Leung and Zernicka-Goetz show that Angiomotin family members prevent the differentiation of inner cell mass cells in the mouse blastocyst, via both Hippo pathway-dependent and -independent mechanisms.
- Chuen Yan Leung
- & Magdalena Zernicka-Goetz
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| Open AccessProteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth
Tumour suppressors can be inactivated in cancer not only as a result of mutation, but also by proteolytic degradation. Here the authors show that, during glioma development, the accumulation of the ubiquitin ligase praja2 sustains tumour growth by degrading MOB1—a core component of the Hippo pathway.
- Luca Lignitto
- , Antonietta Arcella
- & Antonio Feliciello
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The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
It is assumed that budding yeast need to reach a certain size before entering the cell cycle. Here, using imaging and a mathematical model, Ferrezueloet al.show that there is variability in the size of cells entering the cell cycle and this is controlled by growth rate in G1.
- Francisco Ferrezuelo
- , Neus Colomina
- & Martí Aldea
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Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells
The fusion of satellite cells to muscle fibres during adult life is required for both muscle growth and regeneration but it is unknown whether non-muscle cells contribute to this process. Now, Dellavalle and colleagues show that pericytes, cells associated with the vasculature can contribute to both growth and regeneration of muscle fibres.
- A. Dellavalle
- , G. Maroli
- & G. Cossu
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| Open AccessA shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans
What controls the binding partner selection of the target of rapamycin protein, TOR, is unknown. Using theCaenorhabditis elegans tail as a model, Nukazuka et al. determine that signals of semaphorin through plexin control the binding partner selection of TOR and are required for the correct organization of rays in the tail.
- Akira Nukazuka
- , Shusaku Tamaki
- & Shin Takagi