Cell biology articles within Nature

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  • Article |

    MYC dissociation from active promoters alters its interactions with proteins involved in transcription termination and RNA processing, influencing DNA repair and thus, potentially, tumour cell growth.

    • Daniel Solvie
    • , Apoorva Baluapuri
    •  & Martin Eilers

  • Research Briefing |

    Gene expression was assessed in individual liver cells from mice that were infected with the rodent-specific form of the malaria parasite. This revealed that infections of cells in the inner zones of the lobule units that make up the liver are more likely to succeed than are infections in the outer zones.

  • Article |

    Single-cell RNA sequencing and single-molecule RNA transcript imaging have been used to characterize spatially and temporally resolved mouse liver and parasite expression programmes during infection with the rodent malaria parasite Plasmodium berghei ANKA.

    • Amichay Afriat
    • , Vanessa Zuzarte-Luís
    •  & Shalev Itzkovitz

  • Research Briefing |

    The viscosity of extracellular fluid is a key physical cue, but its impact on cell function and cancer-cell dissemination has remained largely unknown. Experiments in various systems reveal that cancer cells sense, respond to and develop memory of the viscosity of extracellular fluid, with high viscosities increasing cell motility and promoting cancer dissemination.

  • News Feature |

    More than a decade ago, scientists started finding peculiar droplets inside cells. Now researchers are trying to work out how these ubiquitous beads form and what they do.

    • Elie Dolgin

  • Article |

    β2-adrenergic receptor(β2AR) signalling induces ERK activity at endosomes, but not at the plasma membrane, and this activity is dependent on active, endosome-localized Gαs and requires ligand-stimulated β2AR endocytosis.

    • Yonghoon Kwon
    • , Sohum Mehta
    •  & Jin Zhang

  • Article
    | Open Access

    The cryo-EM structure of the yeast SEA complex suggests that SEACAT functions as a scaffold for binding TORC1 regulators.

    • Lucas Tafur
    • , Kerstin Hinterndorfer
    •  & Robbie Loewith

  • News & Views |

    Membrane-spanning proteins have many crucial roles in the cell. New findings challenge our current understanding of the route by which such proteins are inserted into the membranes of animal cells.

    • Ben C. Berks

  • Research Briefing |

    Haem, the molecule that gives blood its red colour, is crucial for nearly all life on Earth, but it can be toxic to cells. A protein called HRG-9 has a previously unrecognized role, in various species, in trafficking haem safely from sites where it is synthesized or stored to places where it can be used.

  • Article
    | Open Access

    The adaptor protein AP-1 controls the shutdown of STING signalling through a mechanism in which AP-1 recognizes a dileucine motif in phosphorylated STING, which leads to targeted transport of STING to the endolysosomal system for degradation.

    • Ying Liu
    • , Pengbiao Xu
    •  & Andrea Ablasser

  • Article |

    Detailed mechanistic insight into fetal globin gene induction during hypoxia-associated stress erythropoiesis provides new therapeutic approaches to treat β-haemoglobinopathies, such as sickle cell disease and β-thalassaemia.

    • Ruopeng Feng
    • , Thiyagaraj Mayuranathan
    •  & Mitchell J. Weiss

  • Article
    | Open Access

    Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.

    • Hua Su
    • , Fei Yang
    •  & Michael Karin

  • Article |

    The lysosomal transmembrane protein CLN3 is required for the lysosomal clearance of glycerophosphodiesters in mice and in human cells, suggesting that the loss of CLN3 causes Batten disease in children due to defects in glycerophospholipid metabolism.

    • Nouf N. Laqtom
    • , Wentao Dong
    •  & Monther Abu-Remaileh

  • Outlook |

    Prostate-specific antigen is an established biomarker, but it is flawed. Research into alternatives is starting to get results, but will they reduce mortality?

    • Benjamin Plackett

  • News & Views |

    The hormone auxin regulates plant growth through nuclear co-receptors. A rapid response also occurs at the cell surface after auxin is perceived by the receptor TMK1 and a co-receptor protein. Is ABP1 this co-receptor?

    • Angus S. Murphy
    •  & Wendy A. Peer

  • Article
    | Open Access

    De novo microbial biosynthesis of vindoline and catharanthine using a highly engineered yeast and in vitro chemical coupling to vinblastine is carried out, positioning yeast as a scalable platform to produce many monoterpene indole alkaloids.

    • Jie Zhang
    • , Lea G. Hansen
    •  & Jay D. Keasling

  • News & Views |

    The interior of the cell is organized with the help of dynamic structures that condense like droplets. A timing strategy ensures that cells maintain healthy function by avoiding uncontrolled growth of these condensates.

    • Guillaume Charras
    •  & Martin Lenz

  • Article
    | Open Access

    Endocytosis and degradation of plasma membrane proteins in the axon initial segment, together with the diffusion-barrier mechanism, maintain a polarized distribution of plasma membrane proteins in Caenorhabditis elegans, mouse, rat and human neurons.

    • Kelsie Eichel
    • , Takeshi Uenaka
    •  & Kang Shen

  • Research Briefing |

    Microglia are immune cells that regulate the function and activity of the nervous system. Detailed molecular and spatial studies in mice reveal that different types of neuron govern the density and states of nearby microglia, interactions that can shape local neural circuits.

  • Article
    | Open Access

    Histone deacetylation at the onset of mitosis induces a chromatin-intrinsic phase transition that endows chromosomes with the physical characteristics necessary for their precise movement during cell division.

    • Maximilian W. G. Schneider
    • , Bryan A. Gibson
    •  & Daniel W. Gerlich

  • News & Views |

    An analysis of chromosomes during mitotic cell division reveals that DNA and associated histone proteins condense through a process called phase transition, which helps them to resist the pushing forces involved in mitosis.

    • Kazuhiro Maeshima

  • Article
    | Open Access

    Biochemical and lipidomic analyses identify an anti-ferroptotic function of vitamin K and reveal ferroptosis suppressor protein 1 (FSP1) as the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle.

    • Eikan Mishima
    • , Junya Ito
    •  & Marcus Conrad

  • Article
    | Open Access

    Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that result in non-random aneuploidy landscapes.

    • Sjoerd J. Klaasen
    • , My Anh Truong
    •  & Geert J. P. L. Kops

  • News & Views |

    A single-cell analysis suggests that the 3D location of chromosomes in the cell nucleus contributes to their likelihood of being involved in genomic rearrangements associated with cancer.

    • Krishnendu Guin
    •  & Tom Misteli

  • Article |

    The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

    • Max L. Valenstein
    • , Kacper B. Rogala
    •  & David M. Sabatini

  • Article
    | Open Access

    A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to activate the downstream pathway.

    • Zachary J. Hauseman
    • , Michelle Fodor
    •  & Daniel A. King

  • Article |

    Small intestinal crypts contain twice as many effective stem cells as large intestinal crypts, and this difference is determined by the degree of Wnt-driven retrograde cell movement—which is largely absent in the large intestine—counteracting conveyor-belt-like upward movement.

    • Maria Azkanaz
    • , Bernat Corominas-Murtra
    •  & Jacco van Rheenen

  • Article
    | Open Access

    This study provides a comprehensive spatiotemporal map of human and mouse gonadal differentiation, using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy, which can guide in vitro gonadogenesis.

    • Luz Garcia-Alonso
    • , Valentina Lorenzi
    •  & Roser Vento-Tormo

  • Article
    | Open Access

    Untargeted metabolomics demonstrate that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched, and inosine is identified as a metabolite released during apoptosis regulating thermogenic fat and counteracting obesity.

    • Birte Niemann
    • , Saskia Haufs-Brusberg
    •  & Alexander Pfeifer

  • Article |

    tDeclining YAP/TAZ mechanotransduction drives ageing by unleashing cGAS–STING signalling, a pillar of innate immunity, so sustaining YAP/TAZ mechanosignalling or inhibiting STING present promising approaches for limiting senescence-associated inflammation and improving healthy ageing.

    • Hanna Lucie Sladitschek-Martens
    • , Alberto Guarnieri
    •  & Stefano Piccolo

  • Outlook |

    The hundreds of receptors that give us our sense of smell have been found to have important roles in other parts of the body, and the prospect of targeting them with drugs is growing.

    • Liam Drew

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