Cardiovascular biology articles within Nature

Featured

  • Article |

    Single-cell analysis of blood vessels in the alveolus, the site of chronic disease and virus-induced lung injury, reveals two intermingled endothelial cell types with specialized gas exchange and stem cell functions.

    • Astrid Gillich
    • , Fan Zhang
    •  & Ross J. Metzger

  • Article |

    A genome-wide association study shows that myocardial trabeculae are an important determinant of cardiac performance in the adult heart, identifies conserved pathways that regulate structural complexity and reveals the influence of trabeculae on the susceptibility to cardiovascular disease.

    • Hannah V. Meyer
    • , Timothy J. W. Dawes
    •  & Declan P. O’Regan

  • News & Views |

    An analysis of faecal samples reveals that obese people who take cholesterol-lowering statin drugs have a ‘healthier’ community of gut microorganisms than would be expected. What are the implications of this surprising finding?

    • Peter Libby

  • News & Views |

    Clinicians use ultrasound videos of heartbeats to assess subtle changes in the heart’s pumping function. A method that uses artificial intelligence might simplify these complex assessments when heartbeats are out of rhythm.

    • Partho P. Sengupta
    •  & Donald A. Adjeroh

  • News & Views |

    The activity of calcium channels in the heart increases during what is called the fight-or-flight response. An investigation into the 50-year-old mystery of how this occurs has captured a previously overlooked suspect.

    • Xiaohan Wang
    •  & Richard W. Tsien

  • Article |

    An in vivo approach to identify proteins whose enrichment near cardiac CaV1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.

    • Guoxia Liu
    • , Arianne Papa
    •  & Steven O. Marx

  • News & Views |

    How Nature reported the establishment of a wildlife sanctuary in the Pacific Ocean in 1920, and a wry analysis of whether procreation causes heart attacks.

  • Letter |

    Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury in mice, providing proof-of-principle for the development of immunotherapeutic treatments for cardiac disease.

    • Haig Aghajanian
    • , Toru Kimura
    •  & Jonathan A. Epstein

  • News & Views |

    A mouse model that replicates the clinical features of the most common form of heart failure opens a window on the mechanisms underlying this disease, and could help scientists to explore future therapies.

    • Dulguun Amgalan
    •  & Richard N. Kitsis

  • News & Views |

    The link between sleep and cardiovascular disease is poorly understood. Findings in mice now show that disrupted sleep causes the brain to signal the bone marrow to boost white blood cell production, damaging blood vessels.

    • Alan R. Tall
    •  & Sanja Jelic

  • Letter |

    The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability.

    • Cameron S. McAlpine
    • , Máté G. Kiss
    •  & Filip K. Swirski

  • Letter |

    Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.

    • Mark J. Ranek
    • , Kristen M. Kokkonen-Simon
    •  & David A. Kass

  • News & Views |

    A modified protocol has enabled baboons that received transplanted pig hearts to survive for more than six months. This improvement on previous efforts brings pig-to-human heart transplants a step closer.

    • Christoph Knosalla

  • Letter |

    α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.

    • Matthias Längin
    • , Tanja Mayr
    •  & Jan-Michael Abicht

  • News & Views |

    Increases in biomechanical forces in the liver’s blood vessels have now been shown to activate two mechanosensitive proteins. The proteins trigger blood-vessel cells to deploy regenerative factors that drive liver growth.

    • Sina Y. Rabbany
    •  & Shahin Rafii

  • News & Views |

    An analysis of gene-expression patterns in single cells provides detailed insights into the developmental processes that lead to maturation of the coronary arteries.

    • Arndt F. Siekmann

  • News & Views |

    Bioengineered heart valves are a promising treatment for heart-valve disease, but often undergo mechanical failure when implanted. Computational modelling of the initial valve design has now improved their performance in sheep.

    • Craig A. Simmons

  • Outlook |

    A one-off injection to reduce the risk of cardiovascular disease is now a prospect thanks to advances in gene editing.

    • Anthony King

  • News & Views |

    A clever combination of techniques has enabled, for the first time, simultaneous visualization of the 3D waves of electrical and mechanical activity that are responsible for many cases of sudden cardiac death.

    • José Jalife

  • Letter |

    Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.

    • J. Christoph
    • , M. Chebbok
    •  & S. Luther

  • Outlook |

    Heart disease is a different for women. Researchers must investigate, educate, advocate and legislate to decrease the risks, says Nanette Wenger.

    • Nanette Wenger

  • Letter |

    Deletion of the Hippo pathway component Salvador in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumping function.

    • John P. Leach
    • , Todd Heallen
    •  & James F. Martin

  • Outlook |

    • Herb Brody

  • Outline |

    Many people with critical limb ischaemia have no option but to have the affected limb amputated. Can regenerative medicine offer an alternative?

    • David Holmes

  • News & Views |

    Molecules that block the activity or production of the protein ANGPTL3 have now been found to lower blood levels of lipoproteins and cholesterol in mice and healthy humans, mimicking the protective effects of genetic mutations in ANGPTL3.

    • Sekar Kathiresan

  • Article |

    Lipopolysaccharide derived from gut bacteria can accelerate the formation of cerebral cavernous malformations by activating TLR4 on endothelial cells, and polymorphisms that increase expression of the genes encoding TLR4 or its co-receptor CD14 are associated with higher CCM lesion burden in humans.

    • Alan T. Tang
    • , Jaesung P. Choi
    •  & Mark L. Kahn

  • News & Views |

    Ageing is associated with an increased risk of cardiovascular disease caused by the rupture of inflamed cholesterol plaques in arteries. It emerges that this might be partly due to genetic mutations that cause cancerous changes in white blood cells.

    • Alan R. Tall
    •  & Ross L. Levine

  • News & Views |

    Plaque deposits often occur in curved arterial regions with turbulent blood flow. Endothelial cells have been found to respond to blood flow through a previously unidentified signalling pathway that affects plaque build-up. See Letter p.579

    • Vedanta Mehta
    •  & Ellie Tzima

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