Cancer articles within Nature

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  • Article |

    Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

    • Christopher Abbosh
    • , Alexander M. Frankell
    •  & Charles Swanton

  • Article
    | Open Access

    Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx cohort reveal the role of transcriptional events in tumour evolution.

    • Carlos Martínez-Ruiz
    • , James R. M. Black
    •  & Nicholas McGranahan

  • Article
    | Open Access

    An analysis of whole-genome sequencing data from patients with Barrett’s oesophagus or oesophageal ademocarcinoma shows that extrachromosomal DNA (ecDNA) is strongly associated with cancer progression, and that a wide range of oncogenes are amplified on ecDNAs.

    • Jens Luebeck
    • , Alvin Wei Tian Ng
    •  & Paul S. Mischel

  • News & Views |

    A protein from Epstein–Barr virus called EBNA1 has been shown to bind to and break human chromosome 11, producing instability in the genome that might cause a predisposition to cancer.

    • Lori Frappier

  • News & Views |

    Assessing the genetic and cellular changes that underlie human lung cancer as it evolves could aid the development of treatments. The TRACERx project reports data from studies tracking the disease.

    • Tikvah K. Hayes
    •  & Matthew Meyerson

  • News & Views |

    A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation.

    • David H. Wang

  • Article
    | Open Access

    A longitudinal evolutionary analysis of 126 lung cancer patients with metastatic disease reveals the timing of metastatic divergence, modes of dissemination and the genomic events subject to selection during the metastatic transition.

    • Maise Al Bakir
    • , Ariana Huebner
    •  & Charles Swanton

  • Article |

    Combining genome-wide CRISPR screens with massively parallel analyses of human and random DNA sequences reveal a unified mechanism for the surveillance and evolution of translation products from annotated noncoding DNA.

    • Jordan S. Kesner
    • , Ziheng Chen
    •  & Xuebing Wu

  • News & Views |

    Air pollution is associated with the development of lung cancer. Analysis of clinical samples and mouse cancer models suggests that inflammation and a tumour-promotion process induced by polluted air are the major culprits.

    • Allan Balmain

  • Article |

    Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • , Emilia L. Lim
    •  & Charles Swanton

  • News & Views |

    Unusual metabolic pathways used by cancer cells offer possible targets for the development of clinical treatments. One such pathway, involving molecules called polyamines, has been found for pancreatic cancer.

    • Daniel J. Puleston

  • Article |

    Pancreatic ductal adenocarcinoma cells show a specific dependency on ornithine aminotransferase-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for this cancer.

    • Min-Sik Lee
    • , Courtney Dennis
    •  & Nada Y. Kalaany

  • News & Views |

    Cancers that arise from epithelial cells often contain tumour cells that have acquired the characteristics of another cell type — a mesenchymal cell. A mouse model of skin cancer offers insights into why such cells resist treatment.

    • Stephanie Panier

  • Article
    | Open Access

    RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy.

    • Maud Debaugnies
    • , Sara Rodríguez-Acebes
    •  & Cédric Blanpain

  • Research Briefing |

    Cells in which the whole genome has been doubled do not upscale protein synthesis to cope with the increase in DNA. Instead, a shortage of proteins that regulate the packing of DNA in the nucleus leads to poor segregation of DNA structures, which eventually contributes to the development of cancer.

  • Clinical Briefing |

    Leukaemias characterized by the rearrangement of the gene KMT2A or mutation of the NPM1 gene depend on the protein menin. In a first-in-human trial, the menin inhibitor revumenib had minimal severe adverse effects and showed promising clinical activity in individuals with these types of leukaemia.

  • Research Briefing |

    The structure and function of mitochondrial networks were analysed using a combination of approaches to generate detailed maps of these cellular organelles. This analysis revealed that the mitochondria in different subtypes of lung cancer show distinct functional and structural signatures.

  • Article |

    Somatic mutations in MEN1 are identified in patients with leukaemia treated with a novel chromatin-targeting therapy, and the mechanism by which these mutations mediate therapeutic resistance is characterized.

    • Florian Perner
    • , Eytan M. Stein
    •  & Sheng F. Cai

  • Article
    | Open Access

    Revumenib, a potent and selective oral inhibitor of the menin–KMT2A interaction, is associated with a low frequency of treatment-related adverse events and promising clinical activity in patients with relapsed or refractory acute leukaemia.

    • Ghayas C. Issa
    • , Ibrahim Aldoss
    •  & Eytan M. Stein

  • Article
    | Open Access

    A study describing an approach that combines imaging and profiling techniques to structurally and functionally analyse lung cancer in vivo, revealing heterogeneous mitochondrial networks and an association between bioenergetic phenotypes and mitochondrial organization and function.

    • Mingqi Han
    • , Eric A. Bushong
    •  & David B. Shackelford

  • Article |

    Effective anti-PD-1 immunotherapy is associated with the presence of polyclonal CD8+ T cells in the tumour and blood specific for a limited number of immunodominant mutations, which are recurrently recognized over time.

    • Cristina Puig-Saus
    • , Barbara Sennino
    •  & Antoni Ribas

  • Article |

    Logic gating is used to develop a CAR T cell platform that is highly specific and allows the activity of T cells to be restricted to the encounter of two antigens, thus reducing on-target, off-tumour toxicity.

    • Aidan M. Tousley
    • , Maria Caterina Rotiroti
    •  & Robbie G. Majzner

  • News & Views |

    Processes that regulate cell death can rid the body of cancer cells. However, some of these cells have ways to thwart such processes, and one such death-defying mechanism has been found to rely on cellular protrusions called blebs.

    • Michal Reichman-Fried
    •  & Erez Raz

  • News & Views |

    The mechanisms that enable the deadly spread of cancer are not fully understood. It emerges that tumours can signal to the lung to manipulate lipids and so prime the organ to support tumour cells that subsequently spread there.

    • Laura V. Pinheiro
    •  & Kathryn E. Wellen

  • Article
    | Open Access

    Indole-3-acetic acid (3-IAA), a tryptophan metabolite derived from the gut microbiota, is associated with a better response to chemotherapy in pancreatic ductal adenocarcinoma (PDAC), and dietary interventions could have a role in the treatment of PDAC.

    • Joseph Tintelnot
    • , Yang Xu
    •  & Nicola Gagliani

  • News & Views |

    The discovery that molecules produced by gut microorganisms can affect immune cells, and thus the success of chemotherapy for pancreatic cancer, points the way towards the use of nutritional interventions to improve outcomes.

    • Le Li
    •  & Florencia McAllister

  • Research Briefing |

    The activity of two energy-producing metabolic pathways was recorded in different types of healthy tissue and solid-tumour tissue in mice. Comparisons of these measurements revealed that solid tumours make and use energy more slowly than do most healthy tissues, even though tumours grow and show cell division.

  • Article
    | Open Access

    Imaging mass cytometry of human brain tumours provides spatial information that, combined with existing transcriptomic data, reveals the existence of a cellular neighbourhood containing a rare macrophage population associated with prolonged survival.

    • Elham Karimi
    • , Miranda W. Yu
    •  & Logan A. Walsh

  • Article
    | Open Access

    Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy.

    • Mark Sorin
    • , Morteza Rezanejad
    •  & Logan A. Walsh

  • News & Views |

    Daily rhythms affect many aspects of mammalian biology. A discovery in mice that the activity of a key type of immune cell is shaped by such rhythms might have implications for clinical efforts to tackle cancer.

    • Christian H. Gabriel
    •  & Achim Kramer

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