Review Article |
Featured
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Article |
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Mouse models of NF1-associated optic pathway glioma show that tumour initiation and growth are driven by aberrantly high levels of NLGN3 shedding in the optic nerve in response to retinal neuron activity.
- Yuan Pan
- , Jared D. Hysinger
- & David H. Gutmann
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Research Highlights |
Genome shatters in brain cancer
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Letter |
Integrative genomics identifies LMO1 as a neuroblastoma oncogene
Here, single nucleotide variants within the LMO1 locus are shown to be associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. Acquired structural variation in the same locus was also frequently found in neuroblastoma patients, leading to the suggestion that loci identified through genome-wide association studies might be also prone to somatic alterations and therefore identify potential therapy targets and/or biomarkers of tumour aggressiveness.
- Kai Wang
- , Sharon J. Diskin
- & John M. Maris
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Letter |
Glioblastoma stem-like cells give rise to tumour endothelium
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Rong Wang
- , Kalyani Chadalavada
- & Viviane Tabar
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Letter |
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Lucia Ricci-Vitiani
- , Roberto Pallini
- & Ruggero De Maria
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Research Highlights |
Cancer biology: Brain tumour trigger