Featured
-
-
Article
| Open AccessPiezo2 expressed in proprioceptive neurons is essential for skeletal integrity
Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.
- Eran Assaraf
- , Ronen Blecher
- & Elazar Zelzer
-
Article
| Open AccessSMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast RANKL production and excess osteoclastogenesis.
- Zhan Xu
- , Matthew B. Greenblatt
- & Weiguo Zou