Bone development articles within Nature Communications

Featured

• Article
  07 March 2016 | Open Access

  Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

  In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.

  • Defang Li
  • , Jin Liu
  •  & Ge Zhang

• Article
  01 February 2016 | Open Access

  Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration

  The suture mesenchyme has been postulated to act as the niche for stem cells for calvarial bones but the identity of the stem cells is unknown. Here, Maruyama et al.suggest that Axin2 expressing cells act as stem cells not only in craniofacial bone development and homeostasis but in injury-induced repair.

  • Takamitsu Maruyama
  • , Jaeim Jeong
  •  & Wei Hsu

• Article
  01 December 2014 | Open Access

  Evolutionary innovation and conservation in the embryonic derivation of the vertebrate skull

  It is unclear whether the embryonic origin of skull bones is evolutionarily conserved. Here, the authors show that the pattern of cranial development of the Mexican axolotl is similar to that reported for other vertebrates, but the pattern in the African clawed frog, another amphibian, is unique.

  • Nadine Piekarski
  • , Joshua B. Gross
  •  & James Hanken

• Article | 07 November 2014

  NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2

  N-alpha-acetyltransferase 10 (NAA10) regulates cell growth and proliferation. Here the authors show that NAA10 also has a role in osteogenesis, by fine-tuning the activity of the osteogenic transcription factor Runx2.

  • Haejin Yoon
  • , Hye-Lim Kim
  •  & Jong-Wan Park

• Article
  21 October 2014 | Open Access

  Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

  The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells function by inhibiting the osteoclast secretion of sphingosine 1-phosphate, a lipid mediator of osteoclast–osteoblast crosstalk.

  • Johannes Keller
  • , Philip Catala-Lehnen
  •  & Michael Amling

• Article | 18 December 2012

  DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling

  Osteoblasts and endothelial cells have important roles in bone regeneration. Kim and colleagues identify the protein DJ-1 as an angiogenic and osteogenic signalling molecule involved in the cross-talk between these cells and show that DJ-1 promotes bone regeneration and fracture healing in mice.

  • Jung-Min Kim
  • , Hong-In Shin
  •  & Pann-Ghill Suh

• Article | 09 October 2012

  Insight into the early evolution of the avian sternum from juvenile enantiornithines

  The keeled sternum is a distinct skeletal element in extant birds. In this study, specimens of juvenile extinct birds—Enantiornithes—from the Early Cretaceous show a unique sequence of development in the sternum, suggesting differences between living birds and this extinct clade.

  • Xiaoting Zheng
  • , Xiaoli Wang
  •  & Zhonghe Zhou