Blood flow articles within Nature Communications

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  • Article
    | Open Access

    Endothelial Sirtuin1 downregulation in metabolic disorders causes vascular dysfunction and inflammation. Here, the authors show that deficiency of endothelial Sirtuin1, while having deleterious effects on the vasculature, stimulates skeletal muscle insulin sensitivity and improves glucose disposal.

    • Qiuxia Li
    • , Quanjiang Zhang
    •  & Kaikobad Irani

  • Article
    | Open Access

    In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.

    • T. C. Stevenson Keller IV
    • , Christophe Lechauve
    •  & Brant E. Isakson

  • Article
    | Open Access

    The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.

    • Patrick S. Hosford
    • , Jack A. Wells
    •  & Alexander V. Gourine

  • Article
    | Open Access

    Physiological matching of blood flow to the demand for oxygen by the heart is required for sustained cardiac health, yet the underlying mechanisms are obscure. Here, the authors report a key role for acute modifications to the redox state of intracellular pyridine nucleotides in coronary smooth muscle and their impact on voltage-gated K + channels in metabolic vasodilation

    • Marc M. Dwenger
    • , Sean M. Raph
    •  & Matthew A. Nystoriak

  • Article
    | Open Access

    Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to clearing their neurotoxic waste. Here, the authors analyse blood flow simulations to establish the physical laws linking the microvascular architecture to the macroscopic transport properties that control oxygen supply and waste clearance.

    • Florian Goirand
    • , Tanguy Le Borgne
    •  & Sylvie Lorthois

  • Article
    | Open Access

    Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.

    • Xinchen Du
    • , Le Wu
    •  & Meifeng Zhu

  • Article
    | Open Access

    Theta and gamma rhythms are essential to ensure timely communication between brain structures during locomotion. Here the authors investigate the association between cerebral blood flow and neural oscillations in freely behaving mice running a linear track.

    • Antoine Bergel
    • , Elodie Tiran
    •  & Ivan Cohen

  • Article
    | Open Access

    Monitoring hemodynamics in the brain is important in understanding medical imaging data and mechanisms of disease. Here the authors use high-throughput two-photon microscopy with an axially-extended Bessel focus to measure vessel size and blood flow down to capillary scale in the awake mouse brain.

    • Jiang Lan Fan
    • , Jose A. Rivera
    •  & Na Ji

  • Article
    | Open Access

    Necrotizing enterocolitis (NEC) is one of the most lethal gastrointestinal emergencies in neonates needing precision treatment. Here the authors show that remote ischemic conditioning is a non-invasive therapeutic method that enhances blood flow in the intestine, reduces damage, and improves NEC outcome.

    • Yuhki Koike
    • , Bo Li
    •  & Agostino Pierro

  • Article
    | Open Access

    Early stages of the novel coronavirus disease (COVID-19) have been associated with silent hypoxia and poor oxygenation despite relatively small fractions of afflicted lung. Here, the authors present a mathematical model which reproduces the vascular pulmonary mechanisms observed in patients with early COVID-19.

    • Jacob Herrmann
    • , Vitor Mori
    •  & Béla Suki

  • Article
    | Open Access

    Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA. Here, Henslee and colleagues show that circadian rhythms in isolated human red blood cells are dependent on rhythmic transport of K+ ions.

    • Erin A. Henslee
    • , Priya Crosby
    •  & Fatima H. Labeed

  • Article
    | Open Access

    The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • , Thiago S. Mosqueiro
    •  & M. Luisa Iruela-Arispe

  • Article
    | Open Access

    Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation to affect neutrophil functions in mice.

    • Zhenghui Liu
    • , Tadayuki Yago
    •  & Rodger P. McEver

  • Article
    | Open Access

    TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.

    • Jeffrey T. Kroetsch
    • , Andrew S. Levy
    •  & Steffen-Sebastian Bolz

  • Article
    | Open Access

    The identity of mechanosensors within aortic baroreceptors that sense fluctuations in blood pressure is unclear. Here, Lau et al.show that a cation channel TRPC5 acts as a transducer of mechanical stimuli in aortic baroreceptor neurons in rodents.

    • On-Chai Lau
    • , Bing Shen
    •  & Xiaoqiang Yao

  • Article
    | Open Access

    3D microvessels with complex geometries and intact endothelium can be built in vitro. Using these engineered microvessels, here the authors show that the generation of the pathologic meshwork of the blood protein von Willebrand factor is affected by vessel architecture, flow and the proteolytic activity of ADAMTS13.

    • Ying Zheng
    • , Junmei Chen
    •  & José A. López

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