Biomarkers articles within Nature

Featured

  • Outlook |

    Wearable devices that monitor seizures promise improvements in epilepsy treatments and research.

    • Elie Dolgin

  • Letter |

    Many factors have been proposed as contributors to risk of alcohol abuse, but quantifying their influence has been difficult; here a longitudinal study of a large sample of adolescents and machine learning are used to generate models of predictors of current and future alcohol abuse, assessing the relative contribution of many factors, including life history, individual personality differences, brain structure and genotype.

    • Robert Whelan
    • , Richard Watts
    •  & Veronika Ziesch.

  • Article
    | Open Access

    This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • , Rehan Akbani
    •  & Greg Eley

  • Perspective
    | Open Access

    A checklist of criteria to determine the readiness of high-throughput ‘omics’-based tests for guiding patient therapy in clinical trials is discussed; the checklist, developed by the US National Cancer Institute in collaboration with additional scientists with relevant expertise, provides a framework to evaluate the strength of evidence for a test and outlines practical issues to consider before using the test in a clinical setting, with an aim to avoid premature advancement of omics-based tests in clinical trials.

    • Lisa M. McShane
    • , Margaret M. Cavenagh
    •  & Barbara A. Conley

  • Letter |

    Exploration of the interacting effect of statin exposure and genetic variation on gene expression identifies a cis-eQTL that is differentially associated with expression of the GATM gene, which encodes a rate-limiting enzyme involved in creatine synthesis, and that is associated with incidence of statin-induced myopathy, the major adverse effect of statin treatment.

    • Lara M. Mangravite
    • , Barbara E. Engelhardt
    •  & Ronald M. Krauss

  • News |

    Latest fluorescent probe can detect tuberculosis bacteria using a homemade light box and a mobile-phone camera.

    • Alyssa Joyce

  • Letter |

    The Cancer Cell Line Encyclopedia presents the first results from a large-scale screen of some 947 cancer cell lines with 24 anticancer drugs, with the aim of identifying specific genomic alterations and gene expression profiles associated with selective sensitivity or resistance to potential therapeutic agents.

    • Jordi Barretina
    • , Giordano Caponigro
    •  & Levi A. Garraway

  • Letter |

    Circadian clocks are critical timing regulators of physiology and behaviour that are ubiquitous in eukaryotes. Most mechanistic models of the this clock are based on transcription cycles, but some evidence for post-translational regulation has recently surfaced in plants and cyanobacteria. This is one of two groups demonstrating a role for the oxidation of peroxiredoxin proteins in maintaining an entrainable oscillation in human red blood cells and a unicellular alga. These data indicate a role for non-transcriptional mechanisms in clock models and open the door to future work exploring the connections between the transcriptional and non transcriptional circadian machinery.

    • John S. O’Neill
    • , Gerben van Ooijen
    •  & Andrew J. Millar

  • Outlook |

    Health biomarkers, smart technology and social networks are hastening an era of nutrition tailored to your individual needs but relying on information generated by the crowd.

    • Arran Frood

  • Outlook |

    To have any hope of affecting the course of Parkinson's disease, early diagnosis is essential. Rachel Jones assesses progress so far.

    • Rachel Jones

  • Letter |

    Here, the human immune response to infection with Mycobacterium tuberculosis has been characterized by transcriptional profiling. The results show that active tuberculosis correlates with a particular transcriptional signature that is dominated by a neutrophil-driven interferon-inducible gene profile. The study provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the tuberculosis epidemic.

    • Matthew P. R. Berry
    • , Christine M. Graham
    •  & Anne O’Garra

  • Editorial |

    The reporting of candidate biomarkers for disease must be rigorous to drive translational research.

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