Basal cell carcinoma articles within Nature Communications

Featured

• Article
  02 February 2024 | Open Access

  Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma

  Upregulation of GLI1 of has previously been reported in sonic hedgehog (SHH) driven medulloblastoma and basal cell carcinoma (BCC). Here, the authors find that SHH-inactivation of p38 results in stabilization of the transcription factor GLI1 via dephosphorylation at Ser937, resulting in expression of SHH genes and presenting a potential therapy strategy for medulloblastoma and BCC.

  • Ling-Hui Zeng
  • , Chao Tang
  •  & Jirong Wang

• Article
  03 October 2023 | Open Access

  Uncovering the complex relationship between balding, testosterone and skin cancers in men

  Male-pattern baldness (MPB) is related to dysregulation of androgens. Here, authors show that MPB (but not androgens) is associated with skin cancer risk, particularly in the scalp region, suggesting that sun exposure, rather than androgens, is the main driver.

  • Jue-Sheng Ong
  • , Mathias Seviiri
  •  & Matthew H. Law

• Article
  06 December 2022 | Open Access

  LY6D marks pre-existing resistant basosquamous tumor subpopulations

  The identification of distinct cell populations with cellular plasticity in skin basal cell carcinoma is important for understanding treatment resistance mechanisms. Here, the authors identify the resistant LY6D⁺ basosquamous population that correlates with poor clinical outcomes.

  • Daniel Haensel
  • , Sadhana Gaddam
  •  & Anthony E. Oro

• Article
  09 September 2022 | Open Access

  In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

  Standard assessment of immune infiltration of biopsies is not sufficient to accurately predict response to immunotherapy. Here, the authors show that reflectance confocal microscopy can be used to quantify dynamic vasculature and inflammatory features to better predict treatment response in skin cancers.

  • Aditi Sahu
  • , Kivanc Kose
  •  & Milind Rajadhyaksha

• Article
  20 August 2022 | Open Access

  Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

  The role of reciprocal tumour-stroma interactions in tumour invasion remains poorly characterised. Here, single-cell and spatial transcriptomics identifies the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche.

  • Laura Yerly
  • , Christine Pich-Bavastro
  •  & François Kuonen

• Article
  26 February 2021 | Open Access

  Mechanochemical control of epidermal stem cell divisions by B-plexins

  It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.

  • Chen Jiang
  • , Ahsan Javed
  •  & Thomas Worzfeld

• Article
  08 January 2021 | Open Access

  Disease risk scores for skin cancers

  Predicting who will develop skin cancer is difficult. Here, the authors from 23andMe developed a polygenic risk score for skin cancer based on a questionnaire and genetic data from more than 210,000 individuals and suggest that the score could be used in early screening programmes.

  • Pierre Fontanillas
  • , Babak Alipanahi
  •  & Adam Auton

• Article
  09 April 2015 | Open Access

  New basal cell carcinoma susceptibility loci

  Basal cell carcinoma is a common cancer among people of European ancestry, with associated high economic costs to monitor and treat. Here Stacey et al.conduct a genome-wide association study on Icelandic and other European populations, identifying four novel loci associated with cancer susceptibility.

  • Simon N. Stacey
  • , Hannes Helgason
  •  & Kari Stefansson