Bacterial infection articles within Nature

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  • Article
    | Open Access

    Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.

    • Kerttu Majander
    • , Marta Pla-Díaz
    •  & Verena J. Schuenemann

  • Article |

    Ferrosome organelles produced by Clostridioides difficile are required to support colonization of the inflamed gut, highlighting the potential of targeting ferrosome formation as an antimicrobial strategy against this important pathogen.

    • Hualiang Pi
    • , Rong Sun
    •  & Eric P. Skaar

  • Article |

    Klunk and colleagues identify signatures of natural selection imposed by Yersinia pestis and demonstrate their effect on genetic diversity and susceptibility to certain diseases in the present day.

    • Jennifer Klunk
    • , Tauras P. Vilgalys
    •  & Luis B. Barreiro

  • Article |

    Caspase-7 cleaves and activates acid sphingomyelinase (ASM), which promotes the repair of gasdermin pores and thereby delays pore-driven lysis to allow other processes such as extrusion or apoptosis to occur before cell death.

    • Kengo Nozaki
    • , Vivien I. Maltez
    •  & Edward A. Miao

  • Article
    | Open Access

    Monitoring of western chimpanzee populations in Guinea-Bissau and Côte d’Ivoire reveals the presence of rare and different genotypes of Mycobacterium leprae, suggesting greater circulation in wild animals than previously thought.

    • Kimberley J. Hockings
    • , Benjamin Mubemba
    •  & Fabian H. Leendertz

  • Article |

    A lead-optimization strategy combining porin permeation properties and biochemical potency leads to development of a new class of antibiotic based on broad inhibition of penicillin-binding proteins from Gram-negative bacteria.

    • Thomas F. Durand-Reville
    • , Alita A. Miller
    •  & Ruben A. Tommasi

  • Article
    | Open Access

    Pneumococcal and rotavirus vaccines have reduced antibiotic consumption substantially among children under five years old in low- and middle-income countries; however, this effect could be doubled if all countries were to implement vaccination programmes and meet universal vaccine coverage targets.

    • Joseph A. Lewnard
    • , Nathan C. Lo
    •  & Ramanan Laxminarayan

  • Article |

    Neonatal mice are protected against infection with the enteric pathogen enterotoxigenic Escherichia coli by maternally derived natural antibodies as well as by maternal commensal microbiota that induce antibodies that recognize antigens expressed by  Enterobacteriaceae.

    • Wen Zheng
    • , Wenjing Zhao
    •  & Dennis L. Kasper

  • Article |

    The receptor FPR1 on human immune cells interacts with Yersinia pestis, mutations in this receptor provide resistance against plague in humans and Fpr1 deficiency enhances survival in mice.

    • Patrick Osei-Owusu
    • , Thomas M. Charlton
    •  & Olaf Schneewind

  • Article |

    Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

    • Peter A. Smith
    • , Michael F. T. Koehler
    •  & Christopher E. Heise

  • Letter |

    Bovine tuberculosis is a major economic burden on the cattle industry, and attempts to control it have been politically controversial; here farm movement and bovine tuberculosis incidence data are used to construct a mechanistic model and tease apart the factors contributing to epidemic bovine tuberculosis spread.

    • Ellen Brooks-Pollock
    • , Gareth O. Roberts
    •  & Matt J. Keeling

  • Outlook |

    It's time to use viruses that kill bacteria again, say Shigenobu Matsuzaki, Jumpei Uchiyama, Iyo Takemura-Uchiyama and Masanori Daibata.

    • Shigenobu Matsuzaki
    • , Jumpei Uchiyama
    •  & Masanori Daibata

  • Outlook |

    In the face of more drug-resistant bugs and fewer new drugs, partnerships promise a resurgence of antibiotics.

    • Mike May

  • Outlook |

    Science goes back to nature to decipher and disrupt the mechanisms by which germs evade antibiotics.

    • Bill Cannon

  • Outlook |

    New antibiotic treatments could be found by combining novel and existing drugs, in drug-free nanoparticles, or at the bottom of the sea.

    • Katharine Gammon

  • Outlook |

    Tuberculosis is one of the world's most lethal infectious diseases. Further progress in consigning it to the past is a massive challenge. By Tom Paulson.

    • Tom Paulson

  • Outlook |

    Most people infected with Mycobacterium tuberculosis never get the disease, but predicting who will is turning out to be a complex problem.

    • Courtney Humphries

  • Outlook |

    Once tuberculosis takes hold in a population it can be hard to control, but scientists are finding new ways to understand and stop its spread.

    • Ewen Callaway

  • Article |

    Mutations in the ubiquitin ligase parkin are associated with increased susceptibility to Parkinson’s disease; parkin is already known to have a role in mitophagy and this work identifies a new innate immunity role for parkin in ubiquitin-mediated autophagy of intracellular bacterial pathogens.

    • Paolo S. Manzanillo
    • , Janelle S. Ayres
    •  & Jeffery S. Cox

  • Article |

    This study shows that most known mediators of immunity, such as TLR2, MyD88, T cells or B cells, and neutrophils and monocytes, are dispensable for pain produced by Staphylococcus aureus infection; instead, bacterial products, such as N-formylated peptides and α-haemolysin, induce pain by directly activating nociceptor neurons, which in turn modulate inflammation.

    • Isaac M. Chiu
    • , Balthasar A. Heesters
    •  & Clifford J. Woolf

  • Article |

    A Staphylococcus aureus leukotoxin targets cells expressing the chemokine receptor CCR5, a mechanism for the specificity of leukotoxins towards different immune cells.

    • Francis Alonzo III
    • , Lina Kozhaya
    •  & Victor J. Torres

  • Letter |

    The crystal structure of the inner-membrane urea channel HpUreI from Helicobacter pylori, the causative organism of peptic ulcers, reveals how the channel selectively transports urea across the membrane and buffers the pathogen’s periplasmic pH against the acidic gastric environment.

    • David Strugatsky
    • , Reginald McNulty
    •  & Hartmut Luecke

  • News & Views |

    The finding that derivatives of vitamin B can bind to an antigen-presenting protein that stimulates specialized immune cells suggests a novel mechanism by which the immune system detects microbial infections. See Article p.717

    • Wei-Jen Chua
    •  & Ted H. Hansen

  • Letter |

    A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.

    • Luke Jostins
    • , Stephan Ripke
    •  & Judy H Cho

  • Letter |

    In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.

    • Alejandro A. Pezzulo
    • , Xiao Xiao Tang
    •  & Joseph Zabner

  • News & Views |

    Cells can destroy invading bacteria through a digestive process called autophagy. A study finds that sugar molecules, exposed by bacterial damage to the cell's membrane, can trigger this process. See Letter p.414

    • Ju Huang
    •  & John H. Brumell

  • News Feature |

    For decades, Robert Daum has studied the havoc wreaked by methicillin-resistant Staphylococcus aureus. Now he thinks he can stop it for good.

    • Maryn McKenna

  • News & Views |

    The Black Death was one of the most devastating pandemics in human history. The first complete genome sequence of the causative Yersinia pestis bacterium provides a fresh perspective on plague evolution. See Letter p.506

    • Edward C. Holmes

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