Correspondence |
Featured
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Outlook |
Asthma: Breathing new life into research
Asthma was once thought to be a uniform disease triggered by one type of immune cell. Researchers are now revealing the complexity of the condition and hope to hasten new drugs for forms unresponsive to steroids.
- Amy Maxmen
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Outlook |
Treatment: In search of a booster shot
A plethora of therapies can keep the symptoms of allergy under control, but they can't cure. New research aims to prevent allergies from developing in the first place.
- Lauren Gravitz
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Outlook |
Perspective: A human touch
Stephen Holgate argues for a return to more human-centred studies of allergy and asthma.
- Stephen Holgate
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News |
Near-action shots of vital proteins
Structures of G-protein-coupled receptors visualized in near-active states.
- Amy Maxmen
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Article |
Orm family proteins mediate sphingolipid homeostasis
Mutations near the ORMDL3 gene have been associated with childhood asthma. Here, in yeast, Orm proteins are shown to function in sphingolipid homeostasis; alterations in this control result in misregulation of sphingolipid production and accumulation of toxic metabolites. This raises the testable hypothesis that misregulation of sphingolipids may directly contribute to the development of asthma.
- David K. Breslow
- , Sean R. Collins
- & Jonathan S. Weissman
