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| Open AccessCross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trimeric bundle assembly and/or the viral membrane.
- Liam B. King
- , Brandyn R. West
- & Erica Ollmann Saphire
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Article
| Open AccessExploiting light chains for the scalable generation and platform purification of native human bispecific IgG
Bispecific antibodies allow for novel therapeutic approaches but industrial-scale production and immunogenicity represent significant challenges. Here Fischer et al.describe a unique human bispecific antibody format that exploits differing light chains to overcome these obstacles.
- Nicolas Fischer
- , Greg Elson
- & Marie Kosco-Vilbois