Featured
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Article |
Exercise plasma boosts memory and dampens brain inflammation via clusterin
Plasma from voluntarily running mice reduces baseline expression of neuroinflammatory genes and experimentally induced brain inflammation when infused into sedentary mice.
- Zurine De Miguel
- , Nathalie Khoury
- & Tony Wyss-Coray
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Article |
Loss of p53 drives neuron reprogramming in head and neck cancer
MicroRNAs from head and neck cancer cells, shuttled to sensory neurons by extracellular vesicles, cause a shift to an adrenergic neuronal phenotype that promotes tumour progression.
- Moran Amit
- , Hideaki Takahashi
- & Jeffrey N. Myers
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Article |
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.
- Ben W. Dulken
- , Matthew T. Buckley
- & Anne Brunet
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Letter |
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Müller glia in mature mouse retina can be stimulated to produce rod cells; this treatment restores visual responses in a model of congenital blindness.
- Kai Yao
- , Suo Qiu
- & Bo Chen
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Letter |
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Adult neurogenesis in the hippocampus confers resilience to chronic stress in mice by inhibiting the activity of mature granule cells in the ventral dentate gyrus.
- Christoph Anacker
- , Victor M. Luna
- & René Hen
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Letter |
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.
- Shawn F. Sorrells
- , Mercedes F. Paredes
- & Arturo Alvarez-Buylla
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Letter |
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4
This paper identifies a specific population of subventricular-zone-generated astrocytes that increases in population density after cortical injury; these activated astrocytes migrate to the site of injury, unlike described properties for their counterparts residing in the cortex.
- Eric J. Benner
- , Dominic Luciano
- & Chay T. Kuo
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Letter |
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.
- Marlen Knobloch
- , Simon M. G. Braun
- & Sebastian Jessberger
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Letter |
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
Parvalbumin-expressing interneurons regulate the activation and fate choice of adult neural stem cells.
- Juan Song
- , Chun Zhong
- & Hongjun Song
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News & Views |
Gone with the wean
Unlike in other mammals, neuron production in the subventricular region of the human brain becomes depleted in early infancy. This finding calls for a reassessment of the potential role of adult neurogenesis in health and disease. See Letter p.382
- Jon I. Arellano
- & Pasko Rakic
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Molecular landscapes of human hippocampal immature neurons across lifespan