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| Open AccessPKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.
- Coralie Drelon
- , Annabel Berthon
- & Pierre Val
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Article |
PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit
Cushing’s adenoma is associated with somatic mutations in the gene encoding the Cα subunit of protein kinase A. Calebiro et al.reveal that these mutations increase protein kinase A activity by preventing proper assembly of the protein kinase A holoenzyme.
- Davide Calebiro
- , Annette Hannawacker
- & Martin J. Lohse