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| Open AccessIdentification of risk loci for primary aldosteronism in genome-wide association studies
Detection of primary aldosteronism, the most common form of secondary arterial hypertension, is essential for targeted management and prevention of cardiovascular complications. Here, the authors identify genetic loci associated with primary aldosteronism, suggesting new mechanisms of disease.
- Edith Le Floch
- , Teresa Cosentino
- & Maria-Christina Zennaro
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Article
| Open AccessAdrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19
Progressive respiratory failure is the primary cause of death in patients with COVID-19, but pathologies in other tissues may also occur. Here the authors report that adrenal tropism of SARS-CoV-2 is associated with adrenalitis, reduced adrenal cortisol levels and severe adrenal damage in a post-mortem case series of patients with severe fatal COVID-19.
- Tanja Paul
- , Stephan Ledderose
- & Martina Rudelius
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Article
| Open AccessGWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).
- Daniel Eriksson
- , Ellen Christine Røyrvik
- & Eystein Sverre Husebye
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Article
| Open AccessElevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.
- Julia Schewe
- , Eric Seidel
- & Ute Scholl
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Article
| Open AccessPathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism
Mutations in the chloride channel ClC-2 have been found in primary aldosteronism (PA). Here, Göppner et al. generate transgenic mice expressing a mutant form of ClC-2 that displays increased chloride currents like patient mutations, and find it recapitulates the key pathological features of PA.
- Corinna Göppner
- , Ian J. Orozco
- & Thomas J. Jentsch
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Article
| Open AccessArmc5 deletion causes developmental defects and compromises T-cell immune responses
Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival andin vivoT-cell-mediated immune responses.
- Yan Hu
- , Linjiang Lao
- & Jiangping Wu