Acute inflammation articles within Nature

Featured

  • Article
    | Open Access

    Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation mediating wound closure following acute liver injury.

    • K. P. Matchett
    • , J. R. Wilson-Kanamori
    •  & N. C. Henderson

  • Article |

    Viral infection of the respiratory system induces exuberant fibroblast activity, resulting in extensive remodelling of the extracellular matrix and cytokine release, which promote immune cell infiltration of the affected area at the expense of respiratory function.

    • David F. Boyd
    • , E. Kaitlynn Allen
    •  & Paul G. Thomas

  • Article |

    Male patients with COVID-19 have higher plasma levels of innate immune cytokines and chemokines such as IL-8, IL-18 and CCL5 and more non-classical monocytes than female patients, whereas female patients mount robust T cell activation maintained even in older age.

    • Takehiro Takahashi
    • , Mallory K. Ellingson
    •  & Akiko Iwasaki

  • Letter |

    Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.

    • Wenhan Zhu
    • , Maria G. Winter
    •  & Sebastian E. Winter

  • Article |

    After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

    • Shruti Naik
    • , Samantha B. Larsen
    •  & Elaine Fuchs

  • Review Article |

    Extracellular ATP released from cells during inflammatory responses predominantly functions as a signalling molecule through the activation of purinergic P2 receptors and contributes to both beneficial and detrimental inflammatory responses; this review examines P2 receptor signalling via ATP and its effect on the outcome of inflammatory and infectious diseases.

    • Marco Idzko
    • , Davide Ferrari
    •  & Holger K. Eltzschig

  • Letter |

    Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

    • Tim Lämmermann
    • , Philippe V. Afonso
    •  & Ronald N. Germain

  • Outlook |

    COPD is one of the world's biggest killers, but awareness is low, diagnosis is often missed, and in many countries the extent of the problem is not even well-documented.

    • Amber Dance

  • Outlook |

    Scientists have some way to go before they can prove that COPD should be treated as an autoimmune disease, says Steven R. Duncan.

    • Steven R. Duncan

  • Article |

    Salmonella enterica serotype Typhimurium causes acute gut inflammation, which promotes the growth of the pathogen through unknown mechanisms. It is now shown that the reactive oxygen species generated during inflammation react with host-derived sulphur compounds to produce tetrathionate, which the pathogen uses as a terminal electron acceptor to support its growth. The ability to use tetrathionate provides the pathogen with a competitive advantage over bacteria that lack this property.

    • Sebastian E. Winter
    • , Parameth Thiennimitr
    •  & Andreas J. Bäumler

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