Acetyltransferases articles within Nature

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• Article | 13 July 2022

  Mechanisms and inhibition of Porcupine-mediated Wnt acylation

  Cryo-electron microscopy structures of human Porcupine in complex with palmitoleoyl-coenzyme A, the inhibitor LGK974 and its peptide substrate suggest a mechanism for Wnt acylation.

  • Yang Liu
  • , Xiaofeng Qi
  •  & Xiaochun Li

• Letter | 09 September 2010

  MEC-17 is an α-tubulin acetyltransferase

  In eukaryotic cells, a subset of microtubules undergo post-translational modifications such as acetylation, which alters microtubule dynamics and trafficking of motors. These authors identify MEC-17 as the enzyme that directly acetylates α-tubulin in vitro and in vivo and in both invertebrates and vertebrates. This is the identification of the long-sought enzyme that acetylates microtubules.

  • Jyothi S. Akella
  • , Dorota Wloga
  •  & Jacek Gaertig