In Brief in 2020

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  • An article in Cell describes a multi-omic analysis of health risks from spaceflights that implicates mitochondrial stress and dysregulation as key drivers.

    • Dorothy Clyde
    In Brief

  • A study in Genome Biology uses EpiGo-KRAB to analyse the roles of H3K9me3 in genome organization and transcriptional repression and reveals the two functions may be distinct.

    • Dorothy Clyde
    In Brief

  • Jin et al. describe a barcoding approach for analysing metastasis, which they used to generate an organ-specific metastasis map for 500 cancer cell lines.

    • Dorothy Clyde
    In Brief

  • Fozouni et al. describe a CRISPR–Cas13a-based approach for rapid, accurate and portable detection of SARS-CoV-2 in infected individuals.

    • Dorothy Clyde
    In Brief

  • The CRISPR–Cas13 system can be used to knock down circular RNAs (circRNAs) without any impact on related mRNAs, reports a study in Nature Methods.

    • Linda Koch
    In Brief

  • A study in Nature Biotechnology presents a library of transcription factors that are able to induce differentiation of human induced pluripotent stem cells as a resource for cell and tissue engineering.

    • Linda Koch
    In Brief

  • This study reports a compendium of cell-type-specific regulatory annotations that improves the trans-ancestry portability of polygenic risk scores.

    • Linda Koch
    In Brief

  • Corley et al. report fSHAPE, a simplified strategy for in vivo transcriptome-wide footprinting with SHAPE structure-probing techniques.

    • Linda Koch
    In Brief