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The human cytomegalovirus (HCMV) gHgLgO trimer binds with high affinity through the gO subunit to platelet-derived growth factor-α receptor (PDGFRα), which is expressed on fibroblasts but not on epithelial cells.
Shigella flexneri effectors, IpaH1.4 and IpaH2.5, target the E3 linear ubiquitin chain ligase complex (LUBAC) for degradation to inhibit downstream immune signalling during infection.
Influenza virus utilizes splicing factors stored at nuclear speckles through an intranuclear trafficking pathway, which targets viral M1 mRNA to nuclear speckles to promote post-transcriptional splicing and then transports the spliced M2 mRNA from the nucleus.
Antigenic variants from human H1N1 and H3N2 influenza virus libraries possessing random mutations in the haemagglutinin protein, selected by incubation with human and/or ferret convalescent sera, identify escape variants similar to those that have emerged in nature.
Fully replication competent HIV-1 viruses engineered to harbour a foreign epitope tag enabled the unbiased characterization of the cellular interactomes of viral Env and Vif proteins during the natural infection of human lymphocytes.
Whole genome sequencing coupled with assessment of maternal recto–vaginal Streptococcus agalactiae (Group B Streptococcus) colonization, stillbirth and neonatal disease reveals the disease burden and bacterial population structure in coastal Kenya.
Pelagibacter simultaneously produces the biogenic gases methanethiol and dimethyl sulfide from dimethylsulfoniopropionate, regulated by a kinetic switch that balances DMSP allocation between each pathway depending on cellular sulfur demands.
Influenza virus PB2 and M1 induce translocation of host protein CLUH from the cytoplasm to SC35-positive speckles in the nucleoplasm where it has a role in subnuclear transport of the viral ribonucleoprotein.
The translocation assembly module (TAM) of Escherichia coli functions together with the BAM complex to mediate the rapid assembly of usher proteins, the molecular platform important for the biogenesis of bacterial fimbriae.
Global sampling campaigns show that the CHAB-I-5 Roseobacter cluster is abundant in the marine environment, and found from the poles to the tropics. Analysis of the draft genome of strain SB2 reveals adaptation to an oligotrophic lifestyle.
Single-cell measurements of metabolic activities using NanoSIMS reveals that substrate limitation increases phenotypic heterogeneity in Klebsiella oxytoca metabolism, which allows cells to cope with nutrient fluctuations.
Bacteria enriched from surface and plume waters of the 2010 Deepwater Horizon oil spill show that the combined capabilities of community-wide hydrocarbon degradation is greater than its individual components.
Analysis of 60 sites in three ocean basins suggests that overgrowth of fleshy algae on coral reefs supports higher microbial abundances dominated by copiotrophic, potentially pathogenic bacteria via the provision of dissolved inorganic carbon.
Using a bacteriophage infection model that allows physical separation between growth and mutagenesis, this study provides support for the natural selection of random mutations as a basis for adaptation to stress.
Using Volta phase plate cryo-electron tomography, influenza virus haemagluttinin is shown to induce two independent pathways of viral membrane fusion, through lipidic junctions or through a fusion pore.