News & Comment

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

High-resolution connectomics of the human brain is the next frontier in neuroscience.

New twists on established methods and multimodal imaging are poised to bridge gaps between cellular and organismal imaging.

Advances will enable proteome-scale structure determination in cells.

Artificial ECMs enable recapitulation of tissue microenvironments.

Advances in profiling chromosome structure help reveal the regulatory roles of gene organization.

In vivo developmental atlases provide a crucial reference for the new class of stem-cell-derived human embryo models, helping accelerate insights into the mechanisms of human development.

DARLIN enables the generation of a massive diversity of barcodes for in vivo lineage tracing and the combination with single-cell multi-omics measurements.

In vitro embryo models supported by methods development in adjacent fields have revolutionized our understanding of embryogenesis.

Advancements in methods that enable in vitro culture of mammalian embryos have become an essential way of investigating mammalian early embryonic development and modeling developmental and pregnancy-related disorders. Here, we discuss the recent method development in this space and analyze current challenges and future directions.

The creation of multiple stem-cell-derived models of mammalian embryogenesis is opening many new doors to study human development and brings a need for scientists to demonstrate responsible dialog over the associated ethical issues.

Research with human embryos and embryo models, this year’s Method of the Year, can be fraught. In contrast, digital embryos could be studied, even perturbed, in computational what-happens-when experiments.

Increasingly advanced in vitro stem-cell-derived human embryo models raise novel ethical questions and shed a light on long-standing questions regarding research on human embryos.

Recent methodological advances in measurements of geometry and forces in the early embryo and its models are enabling a deeper understanding of the complex interplay of genetics, mechanics and geometry during development.

I discuss how recent advancements in lineage tracing methods have enabled rare insight into the cell fate and trajectory during development.

Labs range in size, and no one size is likely to fit all. Here some researchers share their lab size experiences and preferences.

This month we continue our annual celebration of beautiful images.