News & Comment

Phenotypic screens of a complex in vivo structure predict function for essential genes in the worm.

Two complementary methods facilitate genome-wide enrichment of hydroxymethylated DNA.

A new flow cytometry technology based on mass detection allows a very large number of parameters to be simultaneously measured in single cells.

A single-molecule pull-down method provides a simple way for biologists to examine their favorite protein at the single-molecule level.

Combining proteome analysis with genome sequencing improves gene annotation and yields evidence that some genes presumed to be noncoding are actually expressed.

Complex, curved three-dimensional DNA nanostructures can be created using new DNA origami folding techniques.

A normally undesirable property of chromophores is used in the creation of a genetically encoded tag for correlated light and electron microscopy.

Two new reports describe variants of channelrhodopsin 2 with improved properties.

Phage-assisted continuous evolution of proteins automates and accelerates selection, allowing hundreds of rounds of evolution to occur in a single week.

A paleoenzymology approach yields a thermostable thioredoxin enzyme that is functional at acidic pH; the underlying method could prove effective for generating other enzymes with such properties.

A compound for staining amyloid aggregates is found to slow aging and increase lifespan in Caenorhabditis elegans.

Maps of chromatin-state dynamics identify regulatory elements across nine human cell types.

Nanoparticles made of the natural pigment porphyrin combine desirable properties of both organic and inorganic particles.

A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.

High-coverage sequencing of RNA interference targets gives insight into parasite phenotypes.

Researchers have taken first steps toward functional connectomics. By combining large-scale serial electron microscopy and functional imaging data, the structure of neural networks can be related to their function.

Researchers use light-activated photo-uncaging to dissect the elementary steps in protein kinase signaling networks in living human cells.