News & Comment

Machine learning decodes the hidden rules of enhancers.

Deep Visual Proteomics combines the power of deep-learning-based image analysis with microdissection and ultrasensitive mass spectrometry to provide insights into the spatial proteome.

A newly described fluorescent protein, StayGold, is bright and extremely photostable, enabling extended time-lapse imaging.

TALE-fused deaminases enable C-to-T or A-to-G base editing in human mitochondria.

A coarse-grained model enables simulating droplet formation with low-complexity RNA sequences.

To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.

A chemical cocktail reprograms human somatic cells into pluripotent stem cells.

Cell-free DNA ‘fragmentomics’ empowers cancer detection and classification.

B_net provides a measure of radiation damage suffered by protein crystals during X-ray crystallography.

A genetic tracing approach follows the division history of cells in vivo.

Perturb-map combines multiplex imaging and spatial transcriptomics to dissect complex biological functions from CRISPR screens in tumor tissues.

The MINI2P is a two-photon miniscope that enables robust calcium imaging during mouse behavior.

Long-read proteogenomics helps delineate isoform diversity in full-length proteins.

Single-nuclei isoform RNA sequencing enables cell-type specific isoform analysis in frozen brain samples.

Evolutionary trees link ancient and modern human genomes.

Embryogram allows stress measurements during migration of the lateral line primordium in zebrafish embryos.

A lensless microscope captures 3D fluorescence images of complex biological tissues.

Live imaging enables temporal tracking of immune cell behavior.

Ultra-high-throughput sequence alignment enables identification of >130,000 novel RNA viruses.

Comprehensive modeling of cellular networks of cells with a minimal genome.