News & Comment

Illuminating the brain for optogenetic experiments can have undesirable effects on neural activity.

The concept of reference frames inspires researchers to develop a differential ranking system for measuring relative differential abundance, which does not require information about absolute microbial load.

A newly developed method allows structure elucidation of proteins inside intact mammalian cells, using solid-state NMR spectroscopy.

A humanized version of the RNA-targeting Cas13 can regulate RNA abundance and translation.

DNA microscopy is an optics-free method for encoding physical images in DNA.

Multicolor calcium indicators pave the way to a better understanding of information processing in the brain.

Blocking the active sites of proteins with a photocaged tyrosine allows for temporally precise photoactivation of a wide range of proteins of interest.

Developments in genetically encoded voltage indicators and imaging strategies enable the recording of multiple neurons with good signal-to-noise ratios in behaving mice.

A library of degrons allows tuning of half-life and expression levels of proteins in genetic circuits.

A global-scale survey of the ocean viral metagenome (virome) broadens views on marine viruses and their roles in ecosystems.

Phase separation in combination with spatial targeting allows for selective translation of mRNA within synthetic membraneless organelles.

An improved sequential fluorescence in situ hybridization approach allows one to image the expression of 10,000 genes in single cells.

Hybrid multiplexed sculpted light microscopy enables calcium imaging of volumes as large as half a cubic millimeter.

The elimination of all cross-talk in a signaling pathway turns a yeast cell into a model cell that can sense and report on metabolites.

Interferometric scattering microscopy enables extended monitoring of gold-nanoparticle-labeled membrane proteins with impressive spatiotemporal resolution.

A newly identified bacterial biosynthetic pathway enables the production of nonstandard amino acids.

An optimized chemogenetic tool enables highly specific and potent neuronal manipulations.

Metabolic labeling enables researchers to spatiotemporally assess nascent protein deposition in 3D hydrogels and then study how nascent proteins influence cell behaviors.

Comparisons of genome organization in many individual cells with high-throughput FISH show extensive variation.

Combining photoactivation and spontaneous blinking enables long time-lapse localization microscopy.