Method to Watch in 2022

Lineage tracing methods help unravel complexities of cell state and differentiation programs.

Viral tools are a mainstay in mammalian neuroscience, but there is room for improvement.

Advances in label-free microscopy are expanding experimental observations, from biophysics to cell biology and beyond.

The diverse microbial world provides unprecedented potential for exploring genome editing tools.

Method development is indispensable for obtaining complete genomes, and deciphering them.

High-throughput and ultrasensitive mass spectrometry–based approaches are gaining ground in subcellular compositional analysis.

Probing spatially organized DNA and its interacting elements in single cells will deepen our understanding of cell-type-specific gene regulation.

Emerging algorithms are extracting information about macromolecular motions from cryo-EM data.