Method to Watch in 2014

Methods to profile and characterize the function of noncoding RNAs will emerge.

As the CRISPR-Cas system matures, specificity, efficacy and maybe even a eukaryotic nuclease are being considered.

A closer look into the depths of organs such as the brain is within reach.

Correlated light and electron microscopy (CLEM) is particularly powerful when applied in super-resolution.

Data-independent acquisition (DIA) mass spectrometry may change how proteomic data are generated.

Genetically encoded voltage indicators are on the brink of allowing neuronal activity to be directly imaged in vivo.

Nanopores hold promise for single-protein characterization.

Protein structures can be determined from microcrystals using X-ray and electron diffraction.