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Temporal analysis of relative distances (TARDIS) is a conceptually new alternative to traditional single-particle tracking methods that overcomes challenges associated with high particle density, emitter blinking and spurious localizations.
ARTR-seq uses antibody-guided in situ reverse transcription to efficiently and accurately identify RNA-binding protein target sites in as few as 20 cells, or in a formaldehyde-fixed tissue section. The high temporal resolution of ARTR-seq opens opportunities for the investigation of dynamic RNA-binding protein–RNA interactions.
This work introduces ARTR-seq for in situ measurement of RNA-binding protein (RBP) binding sites, which has been demonstrated in a small number of cells and for capturing dynamic RBP binding within short timeframes.
Neurodesk is a platform for analyzing human neuroimaging data, which provides numerous tools in a containerized form, thereby ensuring reproducibility and portability.
CytoCommunity enables both supervised and unsupervised analyses of spatial omics data in order to identify complex tissue cellular neighborhoods based on cell phenotypes and spatial distributions.
SynapShot combines ddFPs with engineered synaptic adhesion molecules for real-time observation of the structural plasticity of synapses in cultured cells and animals.
SnapATAC2 uses a matrix-free spectral embedding algorithm for nonlinear dimension reduction of single-cell omics data, which shows an improved performance in capturing cellular heterogeneity and scalability for large datasets.
Real-time mid-infrared photothermal imaging of nitrile chameleons enables simultaneous, multiplexed measurement of enzymatic activity in living systems and is poised to reveal the spatiotemporal regulation of enzymes in health and disease.
InfraRed-mediated Image Restoration (IR2) uses deep learning to combine the benefits of deep-tissue imaging with NIR probes and the convenience of imaging with GFP for improved time-lapse imaging of embryogenesis.
Single-cell structure probing of RNA transcripts enables simultaneous determination of transcript secondary structure and abundance in single cells, allowing new insights into RNA structural heterogeneity within and among cells.
Scientists have successes to celebrate but must also cope with the sting of failures. In the way she handles both, Nobel laureate Katalin Karikó inspires others.
As money pours into aging research, the field can combine its many methods to home in on what underpins aging. Approaches differ, but researchers share the desire to not overpromise quick-fix anti-aging methods.
It is the mark of an educated mind to rest satisfied with the degree of precision that the nature of the subject admits and not to seek exactness where only an approximation is possible. —Aristotle