Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Methods that improve DNA synthesis with reduced error rate and those that facilitate cloning of large DNA segments will be valuable in rebuilding genomes and provide a stepping stone on the way to genome design.