Table of contents


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Editorial

Turning a blind eye p1

doi:10.1038/nm0108-1


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News

Climate change concerns prompt improved disease forecasting p3

Amy Coombs

doi:10.1038/nm0108-3


Amidst challenges, UK research hub moves closer to relocation p4

Alisa Opar

doi:10.1038/nm0108-4


Survey hints at uneven adoption of cancer vaccine p5

Barbara Boughton

doi:10.1038/nm0108-5


News in brief pp6 - 7

doi:10.1038/nm0108-6


Q & A: Marc Hodosh p8

Genevive Bjorn

doi:10.1038/nm0108-8


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Correspondence

Problems with the oral polio vaccine p9

Virendra K Bhasin

doi:10.1038/nm0108-9


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Book Review

Cigarettes: down but not out p11

Henry A. Lester reviews The Cigarette Century: The Rise, Fall, and Deadly Persistence of the Product That Defined America by Allan M Brandt

doi:10.1038/nm0108-11


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News and Views

Opening the gateway to tumors pp13 - 14

Michael H Kershaw

doi:10.1038/nm0108-13

See also: Article by Buckanovich et al.


Vasopressin: friend or foe? pp14 - 16

Mark A Knepper & Robert A Star

doi:10.1038/nm0108-14


Salt abuse: the path to hypertension pp16 - 17

Wilhelm Schoner

doi:10.1038/nm0108-16

See also: Letter by Wirth et al.


The movers and shakers of deep brain stimulation pp17 - 19

Wael Asaad & Emad Eskandar

doi:10.1038/nm0108-17

See also: Letter by Bekar et al.


Short-circuit recovery from spinal injury pp19 - 20

Dennis J Stelzner

doi:10.1038/nm0108-19

See also: Letter by Courtine et al.


From lung injury to fibrosis pp20 - 21

Klaus Ley & Alexander Zarbock

doi:10.1038/nm0108-20

See also: Article by Tager et al.


Research Highlights p23

doi:10.1038/nm0108-23


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Brief Communication

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge pp25 - 27

Mansun Law, Toshiaki Maruyama, Jamie Lewis, Erick Giang, Alexander W Tarr, Zania Stamataki, Pablo Gastaminza, Francis V Chisari, Ian M Jones, Robert I Fox, Jonathan K Ball, Jane A McKeating, Norman M Kneteman & Dennis R Burton

doi:10.1038/nm1698


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Articles

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy pp28 - 36

Ronald J Buckanovich, Andrea Facciabene, Sarah Kim, Fabian Benencia, Dimitra Sasaroli, Klara Balint, Dionysios Katsaros, Anne O'Brien-Jenkins, Phyllis A Gimotty & George Coukos

doi:10.1038/nm1699

See also: News and Views by Kershaw


Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy pp37 - 44

Jian Qiao, Timothy Kottke, Candice Willmon, Feorillo Galivo, Phonphimon Wongthida, Rosa Maria Diaz, Jill Thompson, Pamela Ryno, Glen N Barber, John Chester, Peter Selby, Kevin Harrington, Alan Melcher & Richard G Vile

doi:10.1038/nm1681


The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak pp45 - 54

Andrew M Tager, Peter LaCamera, Barry S Shea, Gabriele S Campanella, Moisés Selman, Zhenwen Zhao, Vasiliy Polosukhin, John Wain, Banu A Karimi-Shah, Nancy D Kim, William K Hart, Annie Pardo, Timothy S Blackwell, Yan Xu, Jerold Chun & Andrew D Luster

doi:10.1038/nm1685

See also: News and Views by Ley & Zarbock


Modification of kidney barrier function by the urokinase receptor pp55 - 63

Changli Wei, Clemens C Möller, Mehmet M Altintas, Jing Li, Karin Schwarz, Serena Zacchigna, Liang Xie, Anna Henger, Holger Schmid, Maria P Rastaldi, Peter Cowan, Matthias Kretzler, Roberto Parrilla, Moïse Bendayan, Vineet Gupta, Boris Nikolic, Raghu Kalluri, Peter Carmeliet, Peter Mundel & Jochen Reiser

doi:10.1038/nm1696


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Letters

G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension pp64 - 68

Angela Wirth, Zoltán Benyó, Martina Lukasova, Barbara Leutgeb, Nina Wettschureck, Stefan Gorbey, Petra Örsy, Béla Horváth, Christiane Maser-Gluth, Erich Greiner, Björn Lemmer, Günther Schütz, J. Silvio Gutkind & Stefan Offermanns

doi:10.1038/nm1666

See also: News and Views by Schoner


Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury pp69 - 74

Gregoire Courtine, Bingbing Song, Roland R Roy, Hui Zhong, Julia E Herrmann, Yan Ao, Jingwei Qi, V Reggie Edgerton & Michael V Sofroniew

doi:10.1038/nm1682

See also: News and Views by Stelzner


Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor pp75 - 80

Lane Bekar, Witold Libionka, Guo-Feng Tian, Qiwu Xu, Arnulfo Torres, Xiaohai Wang, Ditte Lovatt, Erika Williams, Takahiro Takano, Jurgen Schnermann, Robert Bakos & Maiken Nedergaard

doi:10.1038/nm1693

See also: News and Views by Asaad & Eskandar


Langerhans cell histiocytosis reveals a new IL-17A–dependent pathway of dendritic cell fusion pp81 - 87

Fabienne Coury, Nicola Annels, Aymeric Rivollier, Selma Olsson, Alessandra Santoro, Carole Speziani, Olga Azocar, Monique Flacher, Sophia Djebali, Jacques Tebib, Maria Brytting, R Maarten Egeler, Chantal Rabourdin-Combe, Jan-Inge Henter, Maurizio Arico & Christine Delprat

doi:10.1038/nm1694


Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes pp88 - 92

Olivier Joffre, Thibault Santolaria, Denis Calise, Talal Al Saati, Denis Hudrisier, Paola Romagnoli & Joost P M van Meerwijk

doi:10.1038/nm1688


Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors pp93 - 97

Thomas R Bauer, Jr, James M Allen, Mehreen Hai, Laura M Tuschong, Iram F Khan, Erik M Olson, Rima L Adler, Tanya H Burkholder, Yu-chen Gu, David W Russell & Dennis D Hickstein

doi:10.1038/nm1695


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Technical Report

Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin pp98 - 103

Weiguo Hu, Sean P Ferris, Rodney K Tweten, Gongxiong Wu, Svetlana Radaeva, Bin Gao, Roderick T Bronson, Jose A Halperin & Xuebin Qin

doi:10.1038/nm1674


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