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A sporting chance
Report by Cassandra Willyard

This month, athletes will gather in Beijing to compete for the gold. Some will win, some will lose and some will undoubtedly get injured. What advances in biomedical research might help get injured athletes back on the field faster than ever?


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NEWS & VIEWS

Capturing cancer stem cells
Community corner

CD133 has often been used as a marker of cancer stem cells, but a recent paper calls this premise into question. What does the community think about this finding?


CURRENT ISSUE

Foxa2 and bile acid homeostasis
Article by Bochkis et al.

The transcription factor Foxa2, a key regulator of glucose metabolism, is also crucial for bile acid homestasis in the liver and is misregulated in human cholestatic diseases.


CURRENT ISSUE

Amyloid-beta aggregates in the brains of people with Alzheimer's disease. How large to these aggregates need to be in order to cause the memory deficits that characterize the disease?


CURRENT ISSUE

Two-hit wonder
Letter by Li et al.

Polycystic kidney disease can be caused by germline mutations in PC2 followed by a second 'hit' in the normal allele. But TNF-alpha can also be the second hit, and disease progression in mice can be blocked by anti-TNF-alpha treatment.



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