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Skin is constantly exposed to environmental stressors. Georgopoulos and colleagues show that regulatory T cells respond to the cytokine TSLP produced by stressed keratinocytes and that a loss of skin Treg cell expression of TSLPR leads to lethal inflammation.
The cytokine IL-1β has well-established harmful effects on pancreatic islet function. Donath and colleagues identify an acute wave of postprandial IL-1β release and show that this unexpectedly has a positive effect on insulin secretion and the maintenance of normal metabolic function.
The signaling receptor Notch is required for the generation of marginal zone B cells. Hammad and colleagues show that Notch signaling activates the kinase Taok3 and surface expression of the metalloproteinase ADAM10, which commits transitional B cells to the marginal zone B cell fate.