Combining the precision of CRISPR’s DNA searching ability with the speed and scalability of electronics, we have developed an ‘electronic DNA search engine’, called a CRISPR–Chip, which not only enables DNA detection without amplification, but also showcases the untapped potential of merging molecular biology with nanomaterial electronics. Here, we discuss highlights and challenges on the journey from the initial idea to the commercialization of the CRISPR–Chip.
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References
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Acknowledgements
We acknowledge R. Bundy and M. Heltzen for contributions towards manuscript preparation. The CRISPR–Chip work was supported by discretionary funds to K.A. and National Science Foundation (NSF) award 2048283, National Institutes of Health (NIH) 1R01HL161361 and Cardea Service agreement to the Aran Lab.
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K.A. and B.R.G. prepared the manuscript.
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K.A. is a co-founder of Cardea and CRISPR QC. B.R.G. is a co-founder of Cardea.
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Startup to commercialize the CRISPR–Chip: https://communities.springernature.com/posts/crispr-graphene-enabled-gene-detection
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Aran, K., Goldsmith, B.R. CRISPR quality control on a chip. Nat Rev Bioeng 2, 194–195 (2024). https://doi.org/10.1038/s44222-024-00159-4
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DOI: https://doi.org/10.1038/s44222-024-00159-4