Methionine restriction modulates tumour growth and ageing processes through its influence on diverse metabolic processes. Ji et al. demonstrate that methionine restriction compromises production of hydrogen sulfide (H2S), which impairs H2S-mediated immune signalling and results in increased cancer progression in immunocompetent mice.
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References
Wang, T. J. et al. Nat. Med. 17, 448–453 (2011).
Handzlik, M. K. et al. Nature 614, 118–124 (2023).
Ren, B. et al. Redox Biol. 41, 101940 (2021).
Bárcena, C. et al. Cell Rep. 24, 2392–2403 (2018).
Tönjes, M. et al. Nat. Med. 19, 901–908 (2013).
Krall, A. S., Xu, S., Graeber, T. G., Braas, D. & Christofk, H. R. Nat. Commun. 7, 11457 (2016).
Ji, M. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00854-3 (2023).
Gao, X. et al. Nature 572, 397–401 (2019).
Miller, T. W. et al. J. Biol. Chem. 287, 4211–4221 (2012).
Papapetropoulos, A. et al. Proc. Natl Acad. Sci. USA 106, 21972–21977 (2009).
Sen, N. et al. Mol. Cell 45, 13–24 (2012).
Ma, E. H. et al. Cell Metab. 25, 345–357 (2017).
Roy, D. G. et al. Cell Metab. 31, 250–266.e9 (2020).
Gensollen, T., Iyer, S. S., Kasper, D. L. & Blumberg, R. S. Science 352, 539–544 (2016).
Li, T. et al. Gut 72, 501–511 (2023).
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Joulia, E., Metallo, C.M. Methionine and H2S alter cancer–immune dialogue. Nat Metab 5, 1456–1458 (2023). https://doi.org/10.1038/s42255-023-00862-3
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DOI: https://doi.org/10.1038/s42255-023-00862-3