The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species (ROS). This promotes neuronal function after an active day. Hence, this pathway has an important physiological function beyond its previously described role in ROS-associated diseases, including Alzheimer’s disease.
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Goodman, L.D., Moulton, M.J. & Bellen, H.J. Glial lipid droplets resolve ROS during sleep. Nat Neurosci 27, 610–612 (2024). https://doi.org/10.1038/s41593-023-01546-7
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DOI: https://doi.org/10.1038/s41593-023-01546-7