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Neuroscience

Mapping of the zebrafish brain takes shape

The generation of a whole larval zebrafish brain electron microscopy volume in tandem with automated tools lays the groundwork for producing the first vertebrate brain connectome.

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Fig. 1: Progress in EM volume size and workflow for connectomics.

References

  1. White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. Phil. Trans. R. Soc. Lond. B 314, 1–340 (1986).

    Article  CAS  Google Scholar 

  2. Zheng, Z. et al. Cell 174, 730–743.e22 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. MICrONS Consortium et al. Preprint at bioRxiv https://doi.org/10.1101/2021.07.28.454025 (2021).

  4. Svara, F. et al. Nat. Methods https://doi.org/10.1038/s41592-022-01621-0 (2022).

    Article  PubMed  Google Scholar 

  5. Schubert, P. J. et al. Nat. Methods https://doi.org/10.1038/s41592-022-01624-x (2022).

    Article  PubMed  Google Scholar 

  6. Januszewski, M. et al. Nat. Methods 15, 605–610 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Dorkenwald, S. et al. Nat. Methods 19, 119–128 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Schubert, P. J., Dorkenwald, S., Januszewski, M., Jain, V. & Kornfeld, J. Nat. Commun. 10, 2736 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Boulch, A. Comput. Graph. 88, 24–34 (2020).

    Article  Google Scholar 

  10. Bock, D. D. et al. Nature 471, 177–182 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wanner, A. A., Genoud, C., Masudi, T., Siksou, L. & Friedrich, R. W. Nat. Neurosci. 19, 816–825 (2016).

    Article  CAS  PubMed  Google Scholar 

  12. Ohyama, T. et al. Nature 520, 633–639 (2015).

    Article  CAS  PubMed  Google Scholar 

  13. Schlegel, P., Costa, M. & Jefferis, G. S. Curr. Opin. Insect Sci. 24, 96–105 (2017).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors are supported by funding from the Wellcome Trust (Collaborative Award 203261/Z/16/Z and 221300/Z/20/Z).

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Correspondence to Marta Costa.

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Brooks, P., Champion, A. & Costa, M. Mapping of the zebrafish brain takes shape. Nat Methods 19, 1345–1346 (2022). https://doi.org/10.1038/s41592-022-01637-6

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