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Uncovering an overlooked consequence of phosphorylation: change in cysteine reactivity

Nature Methods volume 19, pages 281–283 (2022)Cite this article

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Global profiling of changes in the reactivity of cysteine residues in response to phosphorylation during mitosis identifies cysteine residues as potential regulatory and drug binding sites on proteins.

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Fig. 1: Chemical profiling of changes in cysteine reactivity upon protein phosphorylation.

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Acknowledgements

This work was supported by the National Institutes of Health grants R01 EB-028628, R01 EB026332, R01 EB026285 and R01 DK130293 to M.B. and a postdoctoral research fellowship by the German Research Foundation (DFG) to M.L.

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  1. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

    Markus Lakemeyer & Matthew Bogyo

  2. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA

    Matthew Bogyo

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  1. Markus Lakemeyer
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  2. Matthew Bogyo
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Correspondence to Markus Lakemeyer or Matthew Bogyo.

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Lakemeyer, M., Bogyo, M. Uncovering an overlooked consequence of phosphorylation: change in cysteine reactivity. Nat Methods 19, 281–283 (2022). https://doi.org/10.1038/s41592-022-01414-5

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