Granulosomes are novel complexes that feature an unexpected partnership between the tetraspanin CD63 and the inflammasome proteins NLRP3 and ASC. Granulosomes assemble on mast cell granules to propel them along microtubules to the plasma membrane for degranulation.
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Acknowledgements
J.M.B. and her lab are supported by National Institutes of Health (NIH) grants AI170832, AI170897 and AI178327, a grant (project 2021299) from the US–Israel Binational Science Foundation, and by the Smart Foundation.
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Blander, J.M., Shi, Y. Pas de deux of NLRP3 and ASC with CD63 on mast cell granules. Nat Immunol 25, 584–586 (2024). https://doi.org/10.1038/s41590-024-01791-3
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DOI: https://doi.org/10.1038/s41590-024-01791-3