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Microglia

APOE set the microglia free

Nature Immunology volume 24, pages 1790–1791 (2023)Cite this article

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Two new studies in which apoE expression in mice is manipulated provide insights into the roles of microglial apoE in neurodegeneration.

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Fig. 1: Microglia and CAM-restricted apoE4 expression inhibits the reactivity of these cells in the context of Alzheimer’s disease.

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Acknowledgements

M.P. is supported by the Sobek Foundation, the Ernst–Jung Foundation, the Klaus Faber Foundation, the Novo Nordisk Prize, the German Research Foundation (SFB 992 project ID 192904750, SFB 1160, SFB 1479 project ID 441891347, TRR 359 project ID 491676693, SFB/TRR167 Project ID259373024 NeuroMac and Gottfried Wilhelm Leibniz Prize) and by the DFG under Germany’s Excellence Strategy (CIBSS – EXC-2189 – project ID390939984).

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  1. Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany

    Emile Wogram & Marco Prinz

  2. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

    Marco Prinz

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  1. Emile Wogram
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  2. Marco Prinz
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Correspondence to Marco Prinz.

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Wogram, E., Prinz, M. APOE set the microglia free. Nat Immunol 24, 1790–1791 (2023). https://doi.org/10.1038/s41590-023-01651-6

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