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COVID-19

Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19

Nature Immunology volume 24, pages 1056–1057 (2023)Cite this article

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COVID-19 vaccines have been successful, but their duration and level of protection could be improved to cover all SARS-CoV-2 variants. A self-assembling enveloped virus-like particle vaccine combining features of mRNA and protein vaccines might provide a way forward.

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Fig. 1: Improved mRNA vaccine produces eVLPs by EABR technology and maintains mRNA vaccine functions.

References

  1. Xu, K., Fan, C., Han, Y., Dai, L. & Gao, G. F. Int. Immunol. 34, 595–607 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Hoffmann, M. A. G. et al. Cell 186, 2380–2391 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Polack, F. P. et al. N. Engl. J. Med. 383, 2603–2615 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Baden, L. R. et al. N. Engl. J. Med. 384, 403–416 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Dai, L. & Gao, G. F. Nat. Rev. Immunol. 21, 73–82 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. Dai, L. et al. N. Engl. J. Med. 386, 2097–2111 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Lee, H. H., Elia, N., Ghirlando, R., Lippincott-Schwartz, J. & Hurley, J. H. Science 322, 576–580 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Votteler, J. & Sundquist, W. I. Cell Host Microbe 14, 232–241 (2013).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China

    George F. Gao

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  1. George F. Gao
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Correspondence to George F. Gao.

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Competing interests

The author is a patent holder on a patent related to the protein subunit vaccine ZF2001 and related vaccines.

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Gao, G.F. Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19. Nat Immunol 24, 1056–1057 (2023). https://doi.org/10.1038/s41590-023-01539-5

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