The cholesterol metabolite receptor GPR183 regulates the secretion of IgA by intestinal plasma cells. This process requires epithelial cell sensing of commensal bacteria and the uptake of dietary cholesterol to generate the GPR183 ligand 7α,25-hydroxycholesterol. Upon GPR183 activation, IgA+ plasma cells remain at the center of intestinal villi and reduce their antibody secretion.
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References
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This is a summary of: Ceglia, S. et al. An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells. Nat. Immunol. https://doi.org/10.1038/s41590-022-01413-w (2023).
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A dietary cholesterol by-product regulates intestinal IgA secretion via GPR183. Nat Immunol 24, 391–392 (2023). https://doi.org/10.1038/s41590-023-01442-z
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DOI: https://doi.org/10.1038/s41590-023-01442-z
