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Generating a genetic road map of childhood acute lymphoblastic leukemia

Nature Genetics volume 54, pages 1267–1268 (2022)Cite this article

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We comprehensively define the genomic landscape of pediatric acute lymphoblastic leukemia (ALL) in the largest cohort assembled to date, and identify new driver genes and biological pathways that are targeted by genetic alteration. These findings serve as a road map to improve our understanding of disease development and identify therapeutic targets in pediatric ALL.

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Fig. 1: Mutation burden in childhood B cell ALL.

References

  1. Inaba, H. & Mullighan, C. G. Pediatric acute lymphoblastic leukemia. Haematologica. 105, 2524–2539 (2020). A Review article that describes risk stratification and treatment approaches in pediatric ALL and advances in our understanding of the disease pathogenesis.

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This is a summary of: Brady, S. W. et al. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat. Genet. https://doi.org/10.1038/s41588-022-01159-x (2022).

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Generating a genetic road map of childhood acute lymphoblastic leukemia. Nat Genet 54, 1267–1268 (2022). https://doi.org/10.1038/s41588-022-01161-5

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