The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers and indicates that monoclonal antibodies used for therapeutic purposes may be less specific than previously thought. Furthermore, trogocytosis may transfer functional properties to new cell types. This process could be used experimentally to trace disease-relevant cell–cell interactions.
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References
Frisch, E. S., Pretzsch, R. & Weber, M. S. A milestone in multiple sclerosis therapy: monoclonal antibodies against CD20 — yet progress continues. Neurotherapeutics 18, 1602–1622 (2021).
von Essen, M. R. et al. Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis. Brain 142, 120–132 (2019).
Ochs, J. et al. Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity. Sci. Transl. Med. 14, eabi4632 (2022).
Quendt, C., Ochs, J., Hausser-Kinzel, S., Hausler, D. & Weber, M. S. Proinflammatory CD20+ T cells are differentially affected by multiple sclerosis therapeutics. Ann. Neurol. 90, 834–839 (2021).
Li, K. et al. Trogocytosis between non-immune cells for cell clearance, and among immune-related cells for modulating immune responses and autoimmunity. Int. J. Mol. Sci. 22, 2236 (2021).
Flanagan, E. P. et al. Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study. Mult. Scler. Relat. Disord. 57, 103352 (2022).
Mando, P., Rivero, S. G., Rizzo, M. M., Pinkasz, M. & Levy, E. M. Targeting ADCC: a different approach to HER2 breast cancer in the immunotherapy era. Breast 60, 15–25 (2021).
Fu, Z., Li, S., Han, S., Shi, C. & Zhang, Y. Antibody drug conjugate: the ″biological missile″ for targeted cancer therapy. Signal Transduct. Target Ther. 7, 93 (2022).
Baba, E. et al. Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand. J. Immunol. 167, 875–883 (2001).
Croft, M., So, T., Duan, W. & Soroosh, P. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229, 173–191 (2009).
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Ochs, J., Häusser-Kinzel, S. & Weber, M.S. Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies. Nat Rev Immunol 23, 539–540 (2023). https://doi.org/10.1038/s41577-023-00920-7
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DOI: https://doi.org/10.1038/s41577-023-00920-7
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Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis
Veterinary Research Communications (2023)